10-Chloro-3-phenyl-6,7-dihydro-pyrido[2,1-a]isoquinolin-4-one

Base Information

• Chemical Name: 10-Chloro-3-phenyl-6,7-dihydro-pyrido[2,1-a]isoquinolin-4-one
• CAS No.: 165611-15-4
• Molecular Formula: C₁₉H₁₄ClNO
• Molecular Weight: 307.779
• Mol file: 165611-15-4.mol

Synonyms:10-Chloro-3-phenyl-6,7-dihydro-pyrido[2,1-a]isoquinolin-4-one

Chemical Property of 10-Chloro-3-phenyl-6,7-dihydro-pyrido[2,1-a]isoquinolin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10-Chloro-3-phenyl-6,7-dihydro-pyrido[2,1-a]isoquinolin-4-one

There total 3 articles about 10-Chloro-3-phenyl-6,7-dihydro-pyrido[2,1-a]isoquinolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

carbon monoxide (201230-82-2) + 1-Bromo-10-chloro-3-phenyl-6,7-dihydro-pyrido[2,1-a]isoquinolin-4-one (164790-63-0) → 10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzoquinolizine-1-carboxylic acid (143943-71-9) + 10-Chloro-3-phenyl-6,7-dihydro-pyrido[2,1-a]isoquinolin-4-one (165611-15-4)

Guidance literature:

With palladium diacetate; [nickel(II)dichloride(1,3-bis(diphenylphosphino)propane)]; potassium hydrogencarbonate; In water; dimethyl sulfoxide; at 95 ℃; for 20h; Yields of byproduct given;

DOI:10.1016/0040-4039(95)00387-R

Reference yield: 85.0%

carbon monoxide (201230-82-2) + (S)-3-ethoxy-pyrrolidine (143943-75-3) + 1-Bromo-10-chloro-3-phenyl-6,7-dihydro-pyrido[2,1-a]isoquinolin-4-one (164790-63-0) → 10-Chloro-3-phenyl-6,7-dihydro-pyrido[2,1-a]isoquinolin-4-one (165611-15-4) + (S)-10-chloro-1-(3-ethoxypyrrolidin-1-yl)-3-phenyl-6,7-dihydro-4H-benzoquinolizin-4-one (143943-73-1)

Guidance literature:

With palladium diacetate; [nickel(II)dichloride(1,3-bis(diphenylphosphino)propane)]; potassium hydrogencarbonate; In acetonitrile; at 95 ℃; for 24h;

DOI:10.1016/0040-4039(95)00387-R

Reference yield: 75.0%

7-chloro-3,4-dihydro-1-methylisoquinoline (88422-95-1) + (Z)-3-Dimethylamino-2-phenyl-acrylic acid ethyl ester (164790-66-3) → 10-Chloro-3-phenyl-6,7-dihydro-pyrido[2,1-a]isoquinolin-4-one (165611-15-4)

Guidance literature:

In acetic acid; at 95 ℃; for 3h;

DOI:10.1016/0040-4039(95)00387-R

upstream raw materials:

carbon monoxide

(S)-3-ethoxy-pyrrolidine

1-Bromo-10-chloro-3-phenyl-6,7-dihydro-pyrido[2,1-a]isoquinolin-4-one

7-chloro-3,4-dihydro-1-methylisoquinoline

Downstream raw materials:

1-Bromo-10-chloro-3-phenyl-6,7-dihydro-pyrido[2,1-a]isoquinolin-4-one