1-Bromo-10-chloro-3-phenyl-6,7-dihydro-pyrido[2,1-a]isoquinolin-4-one

Base Information

• Chemical Name: 1-Bromo-10-chloro-3-phenyl-6,7-dihydro-pyrido[2,1-a]isoquinolin-4-one
• CAS No.: 164790-63-0
• Molecular Formula: C₁₉H₁₃BrClNO
• Molecular Weight: 386.675
• Mol file: 164790-63-0.mol

Synonyms:1-Bromo-10-chloro-3-phenyl-6,7-dihydro-pyrido[2,1-a]isoquinolin-4-one

Chemical Property of 1-Bromo-10-chloro-3-phenyl-6,7-dihydro-pyrido[2,1-a]isoquinolin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Bromo-10-chloro-3-phenyl-6,7-dihydro-pyrido[2,1-a]isoquinolin-4-one

There total 1 articles about 1-Bromo-10-chloro-3-phenyl-6,7-dihydro-pyrido[2,1-a]isoquinolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

10-Chloro-3-phenyl-6,7-dihydro-pyrido[2,1-a]isoquinolin-4-one (165611-15-4) → 1-Bromo-10-chloro-3-phenyl-6,7-dihydro-pyrido[2,1-a]isoquinolin-4-one (164790-63-0)

Guidance literature:

With N-Bromosuccinimide; In acetic acid; at 95 ℃; for 1h;

DOI:10.1016/0040-4039(95)00387-R

Reference yield: 95.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + 1-Bromo-10-chloro-3-phenyl-6,7-dihydro-pyrido[2,1-a]isoquinolin-4-one (164790-63-0) → methyl 10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzoquinolizine-1-carboxylate (104604-73-1)

Guidance literature:

With palladium diacetate; [nickel(II)dichloride(1,3-bis(diphenylphosphino)propane)]; potassium hydrogencarbonate; at 95 ℃; for 8h;

DOI:10.1016/0040-4039(95)00387-R

Reference yield: 90.0%

carbon monoxide (201230-82-2) + 1-Bromo-10-chloro-3-phenyl-6,7-dihydro-pyrido[2,1-a]isoquinolin-4-one (164790-63-0) → 10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzoquinolizine-1-carboxylic acid (143943-71-9) + 10-Chloro-3-phenyl-6,7-dihydro-pyrido[2,1-a]isoquinolin-4-one (165611-15-4)

Guidance literature:

With palladium diacetate; [nickel(II)dichloride(1,3-bis(diphenylphosphino)propane)]; potassium hydrogencarbonate; In water; dimethyl sulfoxide; at 95 ℃; for 20h; Yields of byproduct given;

DOI:10.1016/0040-4039(95)00387-R

upstream raw materials:

10-Chloro-3-phenyl-6,7-dihydro-pyrido[2,1-a]isoquinolin-4-one

Downstream raw materials:

methyl 10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzoquinolizine-1-carboxylate

10-Chloro-3-phenyl-6,7-dihydro-pyrido[2,1-a]isoquinolin-4-one

(S)-10-chloro-1-(3-ethoxypyrrolidin-1-yl)-3-phenyl-6,7-dihydro-4H-benzoquinolizin-4-one

10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzoquinolizine-1-carboxylic acid