3-hydroxy-1-methyl-2-oxo-5-(4-iodophenyl)-2,5-dihydro-1H-pyrrole-4-carboxylic acid ethyl ester

Base Information

• Chemical Name: 3-hydroxy-1-methyl-2-oxo-5-(4-iodophenyl)-2,5-dihydro-1H-pyrrole-4-carboxylic acid ethyl ester
• CAS No.: 1579289-57-8
• Molecular Formula: C₁₄H₁₄INO₄
• Molecular Weight: 387.174

Synonyms:3-hydroxy-1-methyl-2-oxo-5-(4-iodophenyl)-2,5-dihydro-1H-pyrrole-4-carboxylic acid ethyl ester

Chemical Property of 3-hydroxy-1-methyl-2-oxo-5-(4-iodophenyl)-2,5-dihydro-1H-pyrrole-4-carboxylic acid ethyl ester

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Technology Process of 3-hydroxy-1-methyl-2-oxo-5-(4-iodophenyl)-2,5-dihydro-1H-pyrrole-4-carboxylic acid ethyl ester

There total 1 articles about 3-hydroxy-1-methyl-2-oxo-5-(4-iodophenyl)-2,5-dihydro-1H-pyrrole-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

p-(iodophenyl)carboxaldehyde (15164-44-0) + methylamine (74-89-5) + sodium 1,4-diethoxy-1,4-dioxobut-2-en-2-olate (40876-98-0,88330-76-1,125898-38-6) → 3-hydroxy-1-methyl-2-oxo-5-(4-iodophenyl)-2,5-dihydro-1H-pyrrole-4-carboxylic acid ethyl ester (1579289-57-8)

Guidance literature:

p-(iodophenyl)carboxaldehyde; methylamine; sodium 1,4-diethoxy-1,4-dioxobut-2-en-2-olate; In ethanol; at 110 ℃; for 0.333333h; Microwave irradiation;

With hydrogenchloride; In water; pH=4;

DOI:10.1016/j.tetlet.2014.01.106

Reference yield: 70.0%

3-hydroxy-1-methyl-2-oxo-5-(4-iodophenyl)-2,5-dihydro-1H-pyrrole-4-carboxylic acid ethyl ester (1579289-57-8) + 1,2-diamino-benzene (95-54-5) → ethyl 2-(4-iodophenyl)-1-methyl-1H-pyrrolo[2,3-b]quinoxaline-3-carboxylate (1579289-51-2)

Guidance literature:

With acetic acid; In toluene; at 180 ℃; for 0.166667h; Microwave irradiation;

DOI:10.1016/j.tetlet.2014.01.106

Reference yield: 50.0%

3-hydroxy-1-methyl-2-oxo-5-(4-iodophenyl)-2,5-dihydro-1H-pyrrole-4-carboxylic acid ethyl ester (1579289-57-8) + 1,2-diamino-benzene (95-54-5) → ethyl 2-(4-iodophenyl)-1-methyl-2,4-dihydro-1H-pyrrolo[2,3-b]quinoxaline-3-carboxylate (1579289-44-3)

Guidance literature:

With acetic acid; In toluene; at 40 ℃; for 0.05h; Reflux;

DOI:10.1016/j.tetlet.2014.01.106

upstream raw materials:

p-(iodophenyl)carboxaldehyde

methylamine

sodium 1,4-diethoxy-1,4-dioxobut-2-en-2-olate

Downstream raw materials:

ethyl 2-(4-iodophenyl)-1-methyl-2,4-dihydro-1H-pyrrolo[2,3-b]quinoxaline-3-carboxylate

ethyl 2-(4-iodophenyl)-1-methyl-1H-pyrrolo[2,3-b]quinoxaline-3-carboxylate

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