2-(4-bromo-2,5-difluorophenyl)-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-methylpyrimidin-4-amine

Base Information

Chemical Name:2-(4-bromo-2,5-difluorophenyl)-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-methylpyrimidin-4-amine
CAS No.:764708-28-3
Molecular Formula:C₁₉H₁₇BrF₂N₄O
Molecular Weight:435.271
Hs Code.:

Synonyms:2-(4-bromo-2,5-difluorophenyl)-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-methylpyrimidin-4-amine

Suppliers and Price of 2-(4-bromo-2,5-difluorophenyl)-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-methylpyrimidin-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(4-bromo-2,5-difluorophenyl)-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-methylpyrimidin-4-amine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(4-bromo-2,5-difluorophenyl)-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-methylpyrimidin-4-amine

There total 11 articles about 2-(4-bromo-2,5-difluorophenyl)-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-methylpyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 764648-61-5
2-(4-bromo-2,5-difluorophenyl)-4-chloro-6-methylpyrimidine

: 764708-27-2
2-(2-methoxypyridin-4-yl)ethylamine

: 764708-28-3
2-(4-bromo-2,5-difluorophenyl)-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-methylpyrimidin-4-amine

Guidance literature:: With 1,3-dimethyl-2-imidazolidinone; potassium carbonate; at 80 ℃;
DOI:10.1016/j.bmc.2012.06.049

Reference yield:

: 2-(2-methoxypyridin-4-yl)acetonitrile

: 764708-28-3
2-(4-bromo-2,5-difluorophenyl)-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-methylpyrimidin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; ammonium hydroxide / ethanol / 22 h / 20 °C

2: 1,3-dimethyl-2-imidazolidinone; potassium carbonate / 80 °C

With 1,3-dimethyl-2-imidazolidinone; ammonium hydroxide; hydrogen; potassium carbonate; In ethanol;
DOI:10.1016/j.bmc.2012.06.049

Reference yield:

: 58481-11-1
methyl 2-chloroisonicotinate

: 764708-28-3
2-(4-bromo-2,5-difluorophenyl)-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-methylpyrimidin-4-amine

Guidance literature:: Multi-step reaction with 6 steps

1: 1,4-dioxane / 26 h / Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

3: thionyl chloride / 2.25 h / 0 °C

4: 18-crown-6 ether / acetonitrile / 13 h / 20 °C

5: hydrogen; ammonium hydroxide / ethanol / 22 h / 20 °C

6: 1,3-dimethyl-2-imidazolidinone; potassium carbonate / 80 °C

With 1,3-dimethyl-2-imidazolidinone; ammonium hydroxide; lithium aluminium tetrahydride; thionyl chloride; 18-crown-6 ether; hydrogen; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; ethanol; acetonitrile;
DOI:10.1016/j.bmc.2012.06.049