benzyl (2R)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(4-methoxyphenyl)propionylamino]propionyloxy]-4-methylpentanoate

Base Information

Chemical Name:benzyl (2R)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(4-methoxyphenyl)propionylamino]propionyloxy]-4-methylpentanoate
CAS No.:728032-80-2
Molecular Formula:C₃₁H₄₂N₂O₈
Molecular Weight:570.683
Hs Code.:

Synonyms:benzyl (2R)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(4-methoxyphenyl)propionylamino]propionyloxy]-4-methylpentanoate

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Chemical Property of benzyl (2R)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(4-methoxyphenyl)propionylamino]propionyloxy]-4-methylpentanoate

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Technology Process of benzyl (2R)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(4-methoxyphenyl)propionylamino]propionyloxy]-4-methylpentanoate

There total 5 articles about benzyl (2R)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(4-methoxyphenyl)propionylamino]propionyloxy]-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20312-37-2,498-36-2
(R)-2-hydroxy-4-methylpentanoic acid

: 728032-80-2
benzyl (2R)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(4-methoxyphenyl)propionylamino]propionyloxy]-4-methylpentanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / K₂CO₃; tetrabutylammonium iodide / dimethylformamide / 1.5 h / 20 °C

2: 90 percent / DMAP; DCC / CH₂Cl₂ / 19.5 h / 0 - 20 °C

3: TFA / CH₂Cl₂ / 3.5 h / 20 °C

4: 1.47 g / HOBT; DIEA; DCC / tetrahydrofuran / 16.5 h / 0 - 20 °C

With dmap; tetra-(n-butyl)ammonium iodide; potassium carbonate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030555f

Reference yield:

: 68856-96-2
N-(tert-butoxycarbonyl)-O-methyl-D-tyrosine

: 697217-20-2
(R)-2-(3-Amino-propionyloxy)-4-methyl-pentanoic acid benzyl ester

: 728032-80-2
benzyl (2R)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(4-methoxyphenyl)propionylamino]propionyloxy]-4-methylpentanoate

Guidance literature:: With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 - 20 ℃; for 16.5h;
DOI:10.1021/jm030555f

Reference yield:

: 37755-48-9
benzyl (R)-2-hydroxy-4-methylpentanoate

: 728032-80-2
benzyl (2R)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(4-methoxyphenyl)propionylamino]propionyloxy]-4-methylpentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / DMAP; DCC / CH₂Cl₂ / 19.5 h / 0 - 20 °C

2: TFA / CH₂Cl₂ / 3.5 h / 20 °C

3: 1.47 g / HOBT; DIEA; DCC / tetrahydrofuran / 16.5 h / 0 - 20 °C

With dmap; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm030555f