THR 221C

Base Information

• Chemical Name: THR 221C
• CAS No.: 120533-29-1
• Molecular Formula: C₂₀H₂₀N₆O₇S₄
• Molecular Weight: 584.679
• Mol file: 120533-29-1.mol

Synonyms:THR221C

Chemical Property of THR 221C

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (6R,7S)-Cefodizime is an impurity of Cefodizime (C242865), a third generation cephalosporin with a broad spectrum of antibacterial activity. Cefodizime maybe useful in the treatment of otitis media, sinusitis and gynaecological infections, and for the prophylaxis or treatment of surgical infections.

Technology Process of THR 221C

There total 4 articles about THR 221C which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Kenicef (86329-79-5) → 2-<<(2-amino-4-thiazolyl)((Z)-methoxyimino)acetyl>amino>acetoaldehyde (104301-63-5) + 5-carboxymethyl-2-mercapto-4-methyl-1,3-thiazole (34272-64-5) + (6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-methoxyimino]-acetylamino}-3-(5-carboxymethyl-4-methyl-thiazol-2-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid (120533-30-4) + cefodizime (69739-16-8,120533-29-1)

Guidance literature:

With sodium hydroxide; at 18 ℃; for 1h; Yield given;

DOI:10.1248/cpb.37.513

Reference yield:

Kenicef (86329-79-5) → 2-<<(2-amino-4-thiazolyl)((Z)-methoxyimino)acetyl>amino>acetoaldehyde (104301-63-5) + 5-carboxymethyl-2-mercapto-4-methyl-1,3-thiazole (34272-64-5) + (6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-methoxyimino]-acetylamino}-3-(5-carboxymethyl-4-methyl-thiazol-2-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid (120533-30-4) + cefodizime (69739-16-8,120533-29-1)

Guidance literature:

With sodium hydroxide; at 18 ℃; for 1h; degradation in variuos conditions;

DOI:10.1248/cpb.37.513

Reference yield:

Kenicef (86329-79-5) → (-)-(6R,7R)-7-<(Z)-2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido>-3-hydroxymethyl-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid lactone (66340-33-8) + Cefodizime (97180-26-2,120533-29-1)

Guidance literature:

With hydrogenchloride; McIlvaine buffer; In water; at 100 ℃; Mechanism; Product distribution; degradation in various conditions (reagents, temperatures, pH);

DOI:10.1248/cpb.37.367

upstream raw materials:

Kenicef

Refernces

• 1、 -. "Method for producing cephalosporins". Page 3. . Retrieved 2010/02/05.
• 2、 Marunaka,Matsushima,Minami,Azuma,Yoshida,Umeno. "Acidic degradation of cefodizime (THR-221) and structural elucidation of the products. I". . p. 367 - 372. Retrieved 2007/10/02.