4-(Chloromethyl)-2,6-dimethylpyridine

Base Information

• Chemical Name: 4-(Chloromethyl)-2,6-dimethylpyridine
• CAS No.: 120739-87-9
• Molecular Formula: C8H10 Cl N
• Molecular Weight: 155.6247
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID40544332
• Mol file: 120739-87-9.mol

Synonyms:4-(Chloromethyl)-2,6-dimethylpyridine;120739-87-9;Pyridine, 4-(chloromethyl)-2,6-dimethyl- (9CI);SCHEMBL1314802;DTXSID40544332;HHJGMXMMZDNOOO-UHFFFAOYSA-N;2,6-dimethyl isonicotinyl chloride;VEA73987;MFCD13189560;AKOS006385313;AB68655;(2,6-dimethyl-4-pyridyl)methyl chloride;AS-50151;O11086;J-513689

Chemical Property of 4-(Chloromethyl)-2,6-dimethylpyridine

Chemical Property:

• PSA: 12.89000
• LogP: 2.43720
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 155.0501770
• Heavy Atom Count: 10
• Complexity: 95.4

Purity/Quality:

97% ^*data from raw suppliers

4-(Chloromethyl)-2,6-dimethylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=CC(=N1)C)CCl

Technology Process of 4-(Chloromethyl)-2,6-dimethylpyridine

There total 5 articles about 4-(Chloromethyl)-2,6-dimethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2,6-dimethyl-4-pyridinemethanol (18088-01-2) → 2,6-dimethyl-pyridin-4-ylmethyl chloride (120739-87-9)

Guidance literature:

2,6-dimethyl-4-pyridinemethanol; With thionyl chloride; In dichloromethane; at 20 ℃; for 21h;

With water; sodium hydrogencarbonate;

Reference yield:

2,6-dimethyl-4-pyridinemethanol (18088-01-2) + methanesulfonyl chloride (124-63-0) → (2,6-dimethylpyridin-4-yl)methyl methanesulfonate (1352718-87-6) + 2,6-dimethyl-pyridin-4-ylmethyl chloride (120739-87-9)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

2,4,6-trimethyl-pyridine 1-oxide (3376-50-9) → 4,6-dimethyl-pyridin-2-ylmethyl chloride (4472-55-3) + 2,6-dimethyl-pyridin-4-ylmethyl chloride (120739-87-9)

Guidance literature:

With bis(trichloromethyl) carbonate; diisopropylamine; In dichloromethane; at -20 - 20 ℃;

DOI:10.1081/SCC-120028642

upstream raw materials:

2,4,6-trimethyl-pyridine 1-oxide

2,6-dimethyl-4-pyridinemethanol

methanesulfonyl chloride

Downstream raw materials:

(2,6-dimethylpyridin-4-yl)acetonitrile