(2S)-1-(2-ethyl-4-{5-[2-(1-ethyl-propyl)-6-methoxy-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-6-methyl-phenoxy)-3-methylamino-propan-2-ol

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Chemical Name:(2S)-1-(2-ethyl-4-{5-[2-(1-ethyl-propyl)-6-methoxy-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-6-methyl-phenoxy)-3-methylamino-propan-2-ol
CAS No.:1262414-15-2
Molecular Formula:C₂₆H₃₆N₄O₄
Molecular Weight:468.596
Hs Code.:

Synonyms:(2S)-1-(2-ethyl-4-{5-[2-(1-ethyl-propyl)-6-methoxy-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-6-methyl-phenoxy)-3-methylamino-propan-2-ol

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Chemical Property of (2S)-1-(2-ethyl-4-{5-[2-(1-ethyl-propyl)-6-methoxy-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-6-methyl-phenoxy)-3-methylamino-propan-2-ol

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Technology Process of (2S)-1-(2-ethyl-4-{5-[2-(1-ethyl-propyl)-6-methoxy-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-6-methyl-phenoxy)-3-methylamino-propan-2-ol

There total 8 articles about (2S)-1-(2-ethyl-4-{5-[2-(1-ethyl-propyl)-6-methoxy-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-6-methyl-phenoxy)-3-methylamino-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5398-44-7
2,6-dichloropyridine-4-carboxylic acid

: 1262414-15-2
(2S)-1-(2-ethyl-4-{5-[2-(1-ethyl-propyl)-6-methoxy-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-6-methyl-phenoxy)-3-methylamino-propan-2-ol

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydroxide / water / 34 - 70 °C

1.2: 20 °C

2.1: sulfuric acid / 24 h / Reflux

3.1: Pd(dppf) / tetrahydrofuran / 18 h / 85 °C / Inert atmosphere

4.1: sodium hydroxide; water / ethanol / 1 h / 80 °C

5.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.25 h / 20 °C

5.2: 2 h / 20 °C

6.1: 1,4-dioxane / 18 h / 100 °C

7.1: sodium hydroxide / isopropyl alcohol; water / 18 h / 20 °C

8.1: methanol / 3 h / 60 °C / Sealed vial

With water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; sulfuric acid; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol; 3.1: Negishi Coupling Reaction;

Reference yield:

: 42521-10-8
2-chloro-6-methoxyisonicotinic acid methyl ester

: 1262414-15-2
(2S)-1-(2-ethyl-4-{5-[2-(1-ethyl-propyl)-6-methoxy-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-6-methyl-phenoxy)-3-methylamino-propan-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: Pd(dppf) / tetrahydrofuran / 18 h / 85 °C / Inert atmosphere

2.1: sodium hydroxide; water / ethanol / 1 h / 80 °C

3.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.25 h / 20 °C

3.2: 2 h / 20 °C

4.1: 1,4-dioxane / 18 h / 100 °C

5.1: sodium hydroxide / isopropyl alcohol; water / 18 h / 20 °C

6.1: methanol / 3 h / 60 °C / Sealed vial

With water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; Pd(dppf); In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol; 1.1: Negishi Coupling Reaction;