(1-(4-nitro)phenyl)-3-acetyloxyl-4-methylthio-4-phenylsulphonyl butyne

Base Information

Chemical Name:(1-(4-nitro)phenyl)-3-acetyloxyl-4-methylthio-4-phenylsulphonyl butyne
CAS No.:1446871-33-5
Molecular Formula:C₁₉H₁₇NO₆S₂
Molecular Weight:419.479
Hs Code.:

Synonyms:(1-(4-nitro)phenyl)-3-acetyloxyl-4-methylthio-4-phenylsulphonyl butyne

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Chemical Property of (1-(4-nitro)phenyl)-3-acetyloxyl-4-methylthio-4-phenylsulphonyl butyne

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Technology Process of (1-(4-nitro)phenyl)-3-acetyloxyl-4-methylthio-4-phenylsulphonyl butyne

There total 3 articles about (1-(4-nitro)phenyl)-3-acetyloxyl-4-methylthio-4-phenylsulphonyl butyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 35487-34-4
3-(4-nitrophenyl)prop-2-ynal

: 59431-14-0
(methylsulfanyl)methyl phenyl sulfone

: 75-36-5
acetyl chloride

: 1446871-33-5
(1-(4-nitro)phenyl)-3-acetyloxyl-4-methylthio-4-phenylsulphonyl butyne

Guidance literature:: (methylsulfanyl)methyl phenyl sulfone; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h; Inert atmosphere;

3-(4-nitrophenyl)prop-2-ynal; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h; Inert atmosphere;

acetyl chloride; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1080/00397911.2012.729280

Reference yield:

: 61266-32-8
3-(4-nitrophenyl)prop-2-yn-1-ol

: 1446871-33-5
(1-(4-nitro)phenyl)-3-acetyloxyl-4-methylthio-4-phenylsulphonyl butyne

Guidance literature:: Multi-step reaction with 2 steps

1.1: manganese(IV) oxide / chloroform / 5 h / Inert atmosphere; Reflux

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

2.2: 0.17 h / -78 °C / Inert atmosphere

2.3: -78 - 20 °C / Inert atmosphere

With manganese(IV) oxide; n-butyllithium; In tetrahydrofuran; hexane; chloroform;
DOI:10.1080/00397911.2012.729280

Reference yield:

: 636-98-6
p-nitrobenzene iodide

: 1446871-33-5
(1-(4-nitro)phenyl)-3-acetyloxyl-4-methylthio-4-phenylsulphonyl butyne

Guidance literature:: Multi-step reaction with 3 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; diisopropylamine; copper(l) iodide / toluene / 20 °C / Inert atmosphere

2.1: manganese(IV) oxide / chloroform / 5 h / Inert atmosphere; Reflux

3.1: n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

3.2: 0.17 h / -78 °C / Inert atmosphere

3.3: -78 - 20 °C / Inert atmosphere

With manganese(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; chloroform; toluene; 1.1: |Sonogashira Cross-Coupling;
DOI:10.1080/00397911.2012.729280