59431-14-0

Basic information

• Product Name: METHYLTHIOMETHYL PHENYL SULFONE
• Synonyms: METHYLTHIOMETHYL PHENYL SULFONE;LABOTEST-BB LT00452176
• CAS NO: 59431-14-0
• Molecular Formula: C₈H₁₀O₂S₂
• Molecular Weight: 202.29
• Product Categories: Organic Building Blocks;Sulfones;Sulfur Compounds;Building Blocks;Chemical Synthesis;Organic Building Blocks;Sulfur Compounds
• Mol File: 59431-14-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 85-87 °C(lit.)
• Boiling Point: 358.4°C at 760 mmHg
• Flash Point: 170.6°C
• Appearance: /
• Density: 1.251g/cm³
• Vapor Pressure: 5.26E-05mmHg at 25°C
• Refractive Index: 1.567
• CAS DataBase Reference: METHYLTHIOMETHYL PHENYL SULFONE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYLTHIOMETHYL PHENYL SULFONE(59431-14-0)
• EPA Substance Registry System: METHYLTHIOMETHYL PHENYL SULFONE(59431-14-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 59431-14-0(Hazardous Substances Data)

Usage

Uses

Methylthiomethyl phenyl sulfone may be employed:as nucleophilic and electrophilic building block, in the asymmetric synthesis of 6-N-benzoyl-5′-O-benzyl-2′-deoxyadenosine and its anomerin the synthesis of various multidentate methylthio arylethynes (MTA) derivativesas starting reagent in the preparation of methylthio arylbutadiynes (Ar-C=C-C=C-SCH3)

General Description

Methylthiomethyl phenyl sulfone is a sulfone derivative.

InChI:InChI=1/C8H10O2S2/c1-11-7-12(9,10)8-5-3-2-4-6-8/h2-6H,7H2,1H3

Upstream product

• 2949-92-0 methanethiosulfonic acid S-methyl ester 
• 3406-03-9 2-(phenylsulfonyl)acetophenone 
• 16437-69-7 (methylthio)methyl acetate 
• 873-55-2 sodium benzenesulfonate 
• 68305-26-0 S-methyl p-chlorobenzenethiosulfonate 
• 7205-98-3 chloromethyl phenyl sulfone 
• 5188-07-8 sodium thiomethoxide 
• 624-92-0 Dimethyldisulphide 
• 3959-23-7 benzenesulfonylacetic acid 
• 1438396-95-2 (methylsulfinyl)methyl phenyl sulfone 
• 5000-44-2 1-phenylsulfonyl-2-propanone 
• 7605-30-3 ethyl 2-phenylsulfonylacetate 
• 1125-25-3 S-methyl benzenethiosulfonate 
• 190672-15-2 ethyl (methylsulfanyl)phenylsulfonylacetate 

Downstream Products

• 32136-85-9 methylsulphonyl(phenylsulphonyl)methane 
• 162777-18-6 phenyl- sulfone 
• 130649-74-0 ((1E,3E)-1-Methylsulfanyl-penta-1,3-diene-1-sulfonyl)-benzene 
• 89333-90-4 (2-Benzenesulfonyl-2-methylsulfanyl-ethyl)-trimethyl-silane 
• 130359-75-0 (2R,3S,5RS)-1-benzyloxy-2,3-dihydroxy-5-methylthio-5-phenylsulfonylpentane 
• 120-12-7 anthracene 
• 162776-88-7 phenyl sulfone 
• 162776-93-4 phenyl sulfone 
• 60417-17-6 α-Methylthio-α-phenylsulfonylacetaldehyd 
• 764-44-3 cis-1,2-bis(mehylthio)ethylene 
• 764-45-4 trans-1,2-bis-methylsulfanyl-ethene 
• 162777-23-3 Z-1,2-bis(phenylsulfonyl)-1,2-bis(methylthio)-ethylene 
• 64489-06-1 trans-1-(benzylsulfonyl)-2-(trimethylsilyl)ethylene 
• 89333-86-8 (1-Benzenesulfonylmethyl-allyl)-trimethyl-silane 

Relevant articles and documents

New methodology for obtention of some α-methylsulfanyl sulfones, synthetic precursors of carbonyl compounds

The reaction of some α-phenylsulfonyl carboxylic acids with NaH in DMSO and dimethyl disulfide leading to α-methylsulfanyl alkyl phenyl sulfones is described.

Donor substituted sulfonyl carbenes, 2: Organothio sulfonyl carbenes

Organothio sulfonyl carbenes 3 have been generated via ylid thermolysis or via α-elimination starting from α-chloro α-organothio sulfones and their derivatives. They have been captured by suitable nucleophilic trapping reagents (diazomethane, enol ethers, and other). Their nucleophilic carbenoid precursors could be trapped by an electrophilic olefin (ketene dithioacetal S,S-dioxides as Michael acceptors). Stable carbene Z-dimers could be obtained under various conditions. Bromine catalyzed isomerization to E-isomers proved to be reversible.