4-DIMETHYLAMINOBUTYRIC ACID HYDROCHLORIDE

Base Information

• Chemical Name: 4-DIMETHYLAMINOBUTYRIC ACID HYDROCHLORIDE
• CAS No.: 69954-66-1
• Molecular Formula: C6H13 N O2 . Cl H
• Molecular Weight: 167.636
• Hs Code.: 2922499990
• Mol file: 69954-66-1.mol

Synonyms:Butanoicacid, 4-(dimethylamino)-, hydrochloride (9CI); Butyric acid,4-(dimethylamino)-, hydrochloride (6CI,7CI); 4-(Dimethylamino)butanoic acidhydrochloride; 4-(Dimethylamino)butyric acid hydrochloride

Chemical Property of 4-DIMETHYLAMINOBUTYRIC ACID HYDROCHLORIDE

Chemical Property:

• Appearance/Colour: white granular crystalline powder
• Melting Point: 153-155 °C(lit.)
• PSA: 40.54000
• LogP: 1.21480
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive.: Hygroscopic

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(Dimethylamino)butyric acid hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 4-Dimethylaminobutyric acid hydrochloride is used as pharmaceutical intermediates.

Technology Process of 4-DIMETHYLAMINOBUTYRIC ACID HYDROCHLORIDE

There total 7 articles about 4-DIMETHYLAMINOBUTYRIC ACID HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl N,N-dimethyl-4-aminobutanoate (22041-23-2) → 4-(dimethylamino)butyric acid hydrochloride (69954-66-1)

Guidance literature:

With hydrogenchloride; In water; for 18h; Reflux;

DOI:10.1016/j.tet.2011.12.030

Reference yield: 73.0%

1-methyl-pyrrolidin-2-one (872-50-4,26138-58-9) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → 4-(dimethylamino)butyric acid hydrochloride (69954-66-1)

Guidance literature:

1-methyl-pyrrolidin-2-one; With sodium hydroxide; In water; for 10h; Heating;

formaldehyd; With formic acid; In water; for 8h; Heating;

With hydrogenchloride; In water;

DOI:10.1021/ol060585n

Reference yield: 71.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + formic acid (64-18-6) + 4-amino-n-butyric acid (56-12-2) → 4-(dimethylamino)butyric acid hydrochloride (69954-66-1)

Guidance literature:

formaldehyd; formic acid; 4-amino-n-butyric acid; at 60 ℃; for 16h;

With hydrogenchloride;

DOI:10.3390/ijms21197431

upstream raw materials:

formaldehyd

4-(methylamino)butyric acid hydrochloride

1-methyl-pyrrolidin-2-one

ethyl N,N-dimethyl-4-aminobutanoate

Downstream raw materials:

N-(trans-4-methylcyclohexyl)-4-dimethylaminobutylamide

7-chloro-1-[2-methyl-4-(2-methyl-benzoylamino)-benzoyl]-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl 4-dimethylaminobutyrate hydrochloride

N-(1-(3-bromophenylamino)-4-cyanoisoquinolin-7-yl)-4-(dimethylamino)butanamide

benzyl 4-(4-(dimethylamino)butanamido)benzoate

Refernces

• 1、 Huang, Zhaohua Richard,Tipparaju, Suresh Kumar,Kirpotin, Dmitri B.,Pien, Christine,Kornaga, Tad,Noble, Charles O.,Koshkaryev, Alexander,Tran, Jimmy,Kamoun, Walid S.,Drummond, Daryl C.. "Formulation optimization of an ephrin A2 targeted immunoliposome encapsulating reversibly modified taxane prodrugs". . p. 47 - 57. Retrieved 2019/08/20.
• 2、 -. "SANTACRUZAMATE A COMPOSITIONS AND ANALOGS AND METHODS OF USE". Page/Page column 48. . Retrieved 2014/02/16.