2-(3,4-bis(tetrahydropyran-2-yloxy)phenyl)-2-hydroxyacetic acid methyl ester

Base Information

Chemical Name:2-(3,4-bis(tetrahydropyran-2-yloxy)phenyl)-2-hydroxyacetic acid methyl ester
CAS No.:582289-86-9
Molecular Formula:C₁₉H₂₆O₇
Molecular Weight:366.411
Hs Code.:

Synonyms:2-(3,4-bis(tetrahydropyran-2-yloxy)phenyl)-2-hydroxyacetic acid methyl ester

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Chemical Property of 2-(3,4-bis(tetrahydropyran-2-yloxy)phenyl)-2-hydroxyacetic acid methyl ester

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Technology Process of 2-(3,4-bis(tetrahydropyran-2-yloxy)phenyl)-2-hydroxyacetic acid methyl ester

There total 3 articles about 2-(3,4-bis(tetrahydropyran-2-yloxy)phenyl)-2-hydroxyacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 582289-84-7
3,4-bis(tetrahydropyran-2-yloxy)phenylacetic acid methyl ester

: 582289-86-9
2-(3,4-bis(tetrahydropyran-2-yloxy)phenyl)-2-hydroxyacetic acid methyl ester

Guidance literature:: With 2-sulfonyloxaziridine; potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 ℃; for 0.333333h;
DOI:10.1016/S0045-2068(03)00019-1

Reference yield:

: 102-32-9
3,4-dihydroxyphenylacetate

: 582289-86-9
2-(3,4-bis(tetrahydropyran-2-yloxy)phenyl)-2-hydroxyacetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: conc. H₂SO₄ / Heating

2: pyridinium p-tosylate / CH₂Cl₂ / 1 h

3: 85 percent / KHMDS; 2-sulfonyloxaziridine / tetrahydrofuran; toluene / 0.33 h / -78 °C

With 2-sulfonyloxaziridine; sulfuric acid; pyridinium p-toluenesulfonate; potassium hexamethylsilazane; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/S0045-2068(03)00019-1

Reference yield:

: 25379-88-8
2-(3,4-dihydroxyphenyl)acetic acid methyl ester

: 582289-86-9
2-(3,4-bis(tetrahydropyran-2-yloxy)phenyl)-2-hydroxyacetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridinium p-tosylate / CH₂Cl₂ / 1 h

2: 85 percent / KHMDS; 2-sulfonyloxaziridine / tetrahydrofuran; toluene / 0.33 h / -78 °C

With 2-sulfonyloxaziridine; pyridinium p-toluenesulfonate; potassium hexamethylsilazane; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/S0045-2068(03)00019-1