4-(N-((dimethylamino)methylene)sulfamoyl)-2,6-difluorobenzyl methanesulfonate

Base Information

Chemical Name:4-(N-((dimethylamino)methylene)sulfamoyl)-2,6-difluorobenzyl methanesulfonate
CAS No.:1239964-28-3
Molecular Formula:C₁₁H₁₄F₂N₂O₅S₂
Molecular Weight:356.371
Hs Code.:

Synonyms:4-(N-((dimethylamino)methylene)sulfamoyl)-2,6-difluorobenzyl methanesulfonate

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Chemical Property of 4-(N-((dimethylamino)methylene)sulfamoyl)-2,6-difluorobenzyl methanesulfonate

Chemical Property:

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Technology Process of 4-(N-((dimethylamino)methylene)sulfamoyl)-2,6-difluorobenzyl methanesulfonate

There total 5 articles about 4-(N-((dimethylamino)methylene)sulfamoyl)-2,6-difluorobenzyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1239964-27-2
N'-(3,5-difluoro-4-(hydroxymethyl)phenylsulfonyl)-N,N-dimethylformimidamide

: 124-63-0
methanesulfonyl chloride

: 1239964-28-3
4-(N-((dimethylamino)methylene)sulfamoyl)-2,6-difluorobenzyl methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.5h;

Reference yield:

: 210532-25-5
3,5-difluorobenzenesulfonyl chloride

: 1239964-28-3
4-(N-((dimethylamino)methylene)sulfamoyl)-2,6-difluorobenzyl methanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium hydroxide / water; tetrahydrofuran / 1 h / Cooling with ice

2.1: acetonitrile / 1 h

3.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 3 h / -78 °C

3.2: 0.5 h / -78 °C

4.1: sodium tetrahydroborate / methanol / 1 h / 0 °C

5.1: triethylamine / dichloromethane / 0.5 h / 0 °C

With ammonium hydroxide; sodium tetrahydroborate; n-butyllithium; triethylamine; diisopropylamine; In tetrahydrofuran; methanol; hexane; dichloromethane; water; acetonitrile;

Reference yield:

: 140480-89-3
3,5-difluorobenzenesulfonamide

: 1239964-28-3
4-(N-((dimethylamino)methylene)sulfamoyl)-2,6-difluorobenzyl methanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetonitrile / 1 h

2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 3 h / -78 °C

2.2: 0.5 h / -78 °C

3.1: sodium tetrahydroborate / methanol / 1 h / 0 °C

4.1: triethylamine / dichloromethane / 0.5 h / 0 °C

With sodium tetrahydroborate; n-butyllithium; triethylamine; diisopropylamine; In tetrahydrofuran; methanol; hexane; dichloromethane; acetonitrile;