2-(2-bromophenyl)pyrazolo[1,5-a]pyridine

Base Information

• Chemical Name: 2-(2-bromophenyl)pyrazolo[1,5-a]pyridine
• CAS No.: 1206884-54-9
• Molecular Formula: C₁₃H₉BrN₂
• Molecular Weight: 273.132
• Mol file: 1206884-54-9.mol

Synonyms:2-(2-bromophenyl)pyrazolo[1,5-a]pyridine

Chemical Property of 2-(2-bromophenyl)pyrazolo[1,5-a]pyridine

Chemical Property:

Purity/Quality:

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Technology Process of 2-(2-bromophenyl)pyrazolo[1,5-a]pyridine

There total 5 articles about 2-(2-bromophenyl)pyrazolo[1,5-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

benzoyl(pyridin-1-ium-1-yl)amide (23031-08-5) + (E)-1-bromo-2-(2-iodovinyl)benzene (645413-74-7,908333-96-0) → 2-(2-bromophenyl)pyrazolo[1,5-a]pyridine (1206884-54-9)

Guidance literature:

With P(p-CH₃OC₆H₄)3; silver benzoate; palladium(II) bromide; In 1,4-dioxane; at 125 ℃; for 16h; Inert atmosphere;

DOI:10.1021/ol902710f

Reference yield: 60.0%

benzoyl(pyridin-1-ium-1-yl)amide (23031-08-5) + (E)-1-bromo-2-(2-bromovinyl) benzene (430434-57-4) → 2-(2-bromophenyl)pyrazolo[1,5-a]pyridine (1206884-54-9)

Guidance literature:

With palladium bromide; P(p-CH₃OC₆H₄)3; silver benzoate; In 1,4-dioxane; at 125 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jo201303x

Reference yield:

pyridine (110-86-1) → 2-(2-bromophenyl)pyrazolo[1,5-a]pyridine (1206884-54-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: O-(2,4-dinitrophenyl)hydroxylamine / acetonitrile / 24 h / 40 °C / Inert atmosphere

2.1: sodium hydroxide / tetrahydrofuran; water / 0.08 h / 20 °C / Inert atmosphere

2.2: 5 h / Inert atmosphere

3.1: palladium bromide; P(p-CH₃OC₆H₄)3; silver benzoate / 1,4-dioxane / 16 h / 125 °C / Inert atmosphere

With palladium bromide; P(p-CH₃OC₆H₄)3; silver benzoate; O-(2,4-dinitrophenyl)hydroxylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile;

DOI:10.1021/jo201303x

upstream raw materials:

benzoyl(pyridin-1-ium-1-yl)amide

(E)-1-bromo-2-(2-iodovinyl)benzene

pyridine

(E)-1-bromo-2-(2-bromovinyl) benzene