4-[3-(Boc-aMino)propyloxyl]aniline

Base Information

• Chemical Name: 4-[3-(Boc-aMino)propyloxyl]aniline
• CAS No.: 623562-56-1
• Molecular Formula: C14H22N2O3
• Molecular Weight: 266.34
• Mol file: 623562-56-1.mol

Synonyms:4-[3-(Boc-aMino)propyloxyl]aniline

Chemical Property of 4-[3-(Boc-aMino)propyloxyl]aniline

Chemical Property:

• PSA: 73.58000
• LogP: 3.53450

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl (3-(4-aminophenoxy)propyl)carbamate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-[3-(Boc-aMino)propyloxyl]aniline

There total 12 articles about 4-[3-(Boc-aMino)propyloxyl]aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

[3-(4-nitro-phenoxy)-propyl]-carbamic acid tert-butyl ester (623562-63-0) → 1-amino-4-[3-[N-(tert-butoxycarbonyl)amino]propan-1-yloxy]benzene (623562-56-1)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; for 2h; under 2068.65 Torr;

Reference yield: 65.0%

4-amino-phenol (123-30-8) + tert-butyl N-(3-chloropropyl)carbamate (116861-31-5) → 1-amino-4-[3-[N-(tert-butoxycarbonyl)amino]propan-1-yloxy]benzene (623562-56-1)

Guidance literature:

With sodium hydroxide; In N,N-dimethyl-formamide; at 75 ℃; for 2h;

Reference yield:

N-tert-butoxycarbonyl-3-aminopropanol (58885-58-8) → 1-amino-4-[3-[N-(tert-butoxycarbonyl)amino]propan-1-yloxy]benzene (623562-56-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / PPh₃; DEAD / tetrahydrofuran / 20 °C

2: 89 percent / H₂ / 10 percent Pd/C / methanol / 6 h

With hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1039/b211644h

upstream raw materials:

[3-(4-nitro-phenoxy)-propyl]-carbamic acid tert-butyl ester

4-nitro-phenol

N-tert-butoxycarbonyl-3-aminopropanol

di-tert-butyl dicarbonate

Downstream raw materials:

(S)-3-amino-N-[4-(3-tert-butoxycarbonylamino-propoxy)-phenyl]-succinamic acid tert-butyl ester

(S)-N-[4-(3-amino-propoxy)-phenyl]-3-(2-(3-(guanidino)-benzoylamino)-acetylamino)-succinamic acid trifluoroacetate

(S)-N-[4-[3-[[3-[2-[2-[2-[2-[2-[2-[2-[2-[3-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-propionylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-1-oxopropyl]amino]propoxy]-phenyl]-3-[2-[3-[guanidino]-benzoylamino]-acetylamino]-succinamic acid

(S)-N-[4-(3-tert-butoxycarbonylamino-propoxy)-phenyl]-3-(9H-fluoren-9-ylmethoxycarbonylamino )-succinamic acid tert-butyl ester

Refernces

• 1、 Samper, Katia G.,Lorenzo, Julia,Capdevila, Mercè,Palacios, òscar,Bayón, Pau. "Functionalized azobenzene platinum(II) complexes as putative anticancer compounds". . p. 435 - 453. Retrieved 2021/05/11.
• 2、 -. "heteroaromatic macrocyclic derivatives as protein kinase inhibitors". Paragraph 0190; 0210-0212. . Retrieved 2020/09/16.