(R)-4-bromo-2-fluoro-N-(6-(2-methyl-4-pivaloylpiperazin-1-yl)pyridin-3-yl)-3-(trifluoromethoxy)benzamide

Base Information

Chemical Name:(R)-4-bromo-2-fluoro-N-(6-(2-methyl-4-pivaloylpiperazin-1-yl)pyridin-3-yl)-3-(trifluoromethoxy)benzamide
CAS No.:1433280-67-1
Molecular Formula:C₂₃H₂₅BrF₄N₄O₃
Molecular Weight:561.374
Hs Code.:

Synonyms:(R)-4-bromo-2-fluoro-N-(6-(2-methyl-4-pivaloylpiperazin-1-yl)pyridin-3-yl)-3-(trifluoromethoxy)benzamide

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Chemical Property of (R)-4-bromo-2-fluoro-N-(6-(2-methyl-4-pivaloylpiperazin-1-yl)pyridin-3-yl)-3-(trifluoromethoxy)benzamide

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Technology Process of (R)-4-bromo-2-fluoro-N-(6-(2-methyl-4-pivaloylpiperazin-1-yl)pyridin-3-yl)-3-(trifluoromethoxy)benzamide

There total 9 articles about (R)-4-bromo-2-fluoro-N-(6-(2-methyl-4-pivaloylpiperazin-1-yl)pyridin-3-yl)-3-(trifluoromethoxy)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: (R)-4-bromo-2-fluoro-N-(6-(2-methylpiperazin-1-yl)pyridin-3-yl)-3-(trifluoromethoxy)-benzamide di-hydrochloride

: 3282-30-2
pivaloyl chloride

: 1433280-67-1
(R)-4-bromo-2-fluoro-N-(6-(2-methyl-4-pivaloylpiperazin-1-yl)pyridin-3-yl)-3-(trifluoromethoxy)benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1374892-20-2
(R)-3-methyl-4-(5-nitropyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

: 1433280-67-1
(R)-4-bromo-2-fluoro-N-(6-(2-methyl-4-pivaloylpiperazin-1-yl)pyridin-3-yl)-3-(trifluoromethoxy)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen; 20% palladium hydroxide-activated charcoal / methanol

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; 20% palladium hydroxide-activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

Reference yield:

: 163765-44-4
(R)-tert-butyl 3-methylpiperazine-1-carboxylate

: 1433280-67-1
(R)-4-bromo-2-fluoro-N-(6-(2-methyl-4-pivaloylpiperazin-1-yl)pyridin-3-yl)-3-(trifluoromethoxy)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / dimethyl sulfoxide / 100 °C

2: hydrogen; 20% palladium hydroxide-activated charcoal / methanol

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

4: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; 20% palladium hydroxide-activated charcoal; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;