Benzoic acid (2R,3S,4S)-3-hydroxy-4-[(4R,5R)-5-[(S)-1-(4-methoxy-benzyloxy)-propyl]-2-(4-methoxy-phenyl)-2,5-dimethyl-[1,3]dioxolan-4-yl]-2-methyl-pentyl ester

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Chemical Name:Benzoic acid (2R,3S,4S)-3-hydroxy-4-[(4R,5R)-5-[(S)-1-(4-methoxy-benzyloxy)-propyl]-2-(4-methoxy-phenyl)-2,5-dimethyl-[1,3]dioxolan-4-yl]-2-methyl-pentyl ester
CAS No.:114825-81-9
Molecular Formula:C₃₆H₄₆O₈
Molecular Weight:606.756
Hs Code.:

Synonyms:Benzoic acid (2R,3S,4S)-3-hydroxy-4-[(4R,5R)-5-[(S)-1-(4-methoxy-benzyloxy)-propyl]-2-(4-methoxy-phenyl)-2,5-dimethyl-[1,3]dioxolan-4-yl]-2-methyl-pentyl ester

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Chemical Property of Benzoic acid (2R,3S,4S)-3-hydroxy-4-[(4R,5R)-5-[(S)-1-(4-methoxy-benzyloxy)-propyl]-2-(4-methoxy-phenyl)-2,5-dimethyl-[1,3]dioxolan-4-yl]-2-methyl-pentyl ester

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Technology Process of Benzoic acid (2R,3S,4S)-3-hydroxy-4-[(4R,5R)-5-[(S)-1-(4-methoxy-benzyloxy)-propyl]-2-(4-methoxy-phenyl)-2,5-dimethyl-[1,3]dioxolan-4-yl]-2-methyl-pentyl ester

There total 25 articles about Benzoic acid (2R,3S,4S)-3-hydroxy-4-[(4R,5R)-5-[(S)-1-(4-methoxy-benzyloxy)-propyl]-2-(4-methoxy-phenyl)-2,5-dimethyl-[1,3]dioxolan-4-yl]-2-methyl-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 114825-80-8,124987-25-3,124987-26-4
(2R,3S,4S)-4-[(4R,5R)-5-[(S)-1-(4-Methoxy-benzyloxy)-propyl]-2-(4-methoxy-phenyl)-2,5-dimethyl-[1,3]dioxolan-4-yl]-2-methyl-pentane-1,3-diol

: 98-88-4
benzoyl chloride

: 114825-81-9
Benzoic acid (2R,3S,4S)-3-hydroxy-4-[(4R,5R)-5-[(S)-1-(4-methoxy-benzyloxy)-propyl]-2-(4-methoxy-phenyl)-2,5-dimethyl-[1,3]dioxolan-4-yl]-2-methyl-pentyl ester

Guidance literature:: With pyridine; In dichloromethane; Ambient temperature;
DOI:10.1016/S0040-4039(00)96566-3

Reference yield: 84.0%

: 98-88-4
benzoyl chloride

: 114825-80-8,124987-25-3,124987-26-4
(2R,3S,4S,5R,6R,7R)-7-(4-methoxybenzyloxy)-5,6-<1-(4-methoxyphenyl)ethylidenedioxy>-2,4,6-trimethylnonane-1,3-diol

: 114825-81-9
(2R,3S,4S,5R,6R,7R)-1-benzyloxy-7-(4-methoxybenzyloxy)-5,6-<1-(4-methoxyphenyl)ethylenedioxy>-2,4,6-trimethylnonan-3-ol

Guidance literature:: With pyridine; In dichloromethane; for 35h; Ambient temperature;
DOI:10.1248/cpb.37.1160

Reference yield:

: 27150-99-8
1,1-dimethoxy-1-(4-methoxyphenyl)ethane

: 114825-81-9
(2R,3S,4S,5R,6R,7R)-1-benzyloxy-7-(4-methoxybenzyloxy)-5,6-<1-(4-methoxyphenyl)ethylenedioxy>-2,4,6-trimethylnonan-3-ol

Guidance literature:: Multi-step reaction with 11 steps

1: CSA / CH₂Cl₂ / 2 h / Ambient temperature

2: 1N KOH / methanol / 18 h / Ambient temperature

3: 94 percent / oxalyl chloride / CH₂Cl₂; dimethylsulfoxide / 0.5 h / -60 - -50 °C

4: 99 percent / LDA / tetrahydrofuran / -83 deg C, -20 deg C, 2 h

5: 90 percent / Et₃N / benzene / 0.33 h / 7 °C

6: 99 percent / NaOEt / tetrahydrofuran / 3.5 h / Ambient temperature

7: 78 percent / LiAlH₄ / diethyl ether / 2 h / 0 °C

8: m-CPBA / CH₂Cl₂ / 2.5 h / -20 °C

9: 1M n-Bu₄NF / tetrahydrofuran / 5 h / Ambient temperature

10: 46 percent / H₂ / 5percent Pt-C / benzene / 1 h / 8 - 10 °C

11: 84 percent / pyridine / CH₂Cl₂ / 35 h / Ambient temperature

With pyridine; potassium hydroxide; lithium aluminium tetrahydride; oxalyl dichloride; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; hydrogen; sodium ethanolate; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; platinum on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; benzene;
DOI:10.1248/cpb.37.1160