methyl 2-O-benzyl-3-C-nitromethyl-4-(4-methylphenyl)sulfonyl-6-O-triphenylmethyl-α-D-glucopyranoside

Base Information

• Chemical Name: methyl 2-O-benzyl-3-C-nitromethyl-4-(4-methylphenyl)sulfonyl-6-O-triphenylmethyl-α-D-glucopyranoside
• CAS No.: 1198587-45-9
• Molecular Formula: C₄₁H₄₁NO₈S
• Molecular Weight: 707.844
• Mol file: 1198587-45-9.mol

Synonyms:methyl 2-O-benzyl-3-C-nitromethyl-4-(4-methylphenyl)sulfonyl-6-O-triphenylmethyl-α-D-glucopyranoside

Chemical Property of methyl 2-O-benzyl-3-C-nitromethyl-4-(4-methylphenyl)sulfonyl-6-O-triphenylmethyl-α-D-glucopyranoside

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-O-benzyl-3-C-nitromethyl-4-(4-methylphenyl)sulfonyl-6-O-triphenylmethyl-α-D-glucopyranoside

There total 1 articles about methyl 2-O-benzyl-3-C-nitromethyl-4-(4-methylphenyl)sulfonyl-6-O-triphenylmethyl-α-D-glucopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

nitromethane (75-52-5) + methyl 2-O-benzyl-3,4-dideoxy-4-(4-methylphenyl)sulfonyl-6-O-triphenylmethyl-α-D-erythro-hex-3-enopyranoside (1096364-46-3) → methyl 2-O-benzyl-3-C-nitromethyl-4-(4-methylphenyl)sulfonyl-6-O-triphenylmethyl-α-D-glucopyranoside (1198587-45-9)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; Inert atmosphere; Reflux;

DOI:10.1002/ejoc.200900553

Reference yield: 63.0%

methyl 2-O-benzyl-3-C-nitromethyl-4-(4-methylphenyl)sulfonyl-6-O-triphenylmethyl-α-D-glucopyranoside (1198587-45-9) + methanesulfonyl chloride (124-63-0) → methyl 2-O-benzyl-3,4-dideoxy-3-C-nitromethyl-4-(4-methylphenyl)sulfonyl-6-O-mesyl-α-D-glucopyranoside (1198587-49-3)

Guidance literature:

methyl 2-O-benzyl-3-C-nitromethyl-4-(4-methylphenyl)sulfonyl-6-O-triphenylmethyl-α-D-glucopyranoside; With acetyl chloride; In methanol; at 0 ℃; for 4h; Inert atmosphere;

methanesulfonyl chloride; With pyridine; In methanol; at 0 ℃; for 12h; Inert atmosphere;

DOI:10.1002/ejoc.200900553

Reference yield:

methyl 2-O-benzyl-3-C-nitromethyl-4-(4-methylphenyl)sulfonyl-6-O-triphenylmethyl-α-D-glucopyranoside (1198587-45-9) → C41H40O7S (1198587-47-1)

Guidance literature:

methyl 2-O-benzyl-3-C-nitromethyl-4-(4-methylphenyl)sulfonyl-6-O-triphenylmethyl-α-D-glucopyranoside; With potassium tert-butylate; In tert-butyl alcohol; at 20 - 60 ℃; Inert atmosphere;

With potassium permanganate; In water; ethyl acetate; tert-butyl alcohol; at 20 ℃; for 0.333333h; Inert atmosphere;

DOI:10.1002/ejoc.200900553

upstream raw materials:

nitromethane

methyl 2-O-benzyl-3,4-dideoxy-4-(4-methylphenyl)sulfonyl-6-O-triphenylmethyl-α-D-erythro-hex-3-enopyranoside

Downstream raw materials:

C₄₁H₄₀O₇S

methyl 2-O-benzyl-3,4-dideoxy-3-C-nitromethyl-4-(4-methylphenyl)sulfonyl-6-O-mesyl-α-D-glucopyranoside