2-methoxy-N'-[4-(4-methoxybenzyloxy)-quinolin-2-yl]propane-1,3-diamine

Base Information

• Chemical Name: 2-methoxy-N'-[4-(4-methoxybenzyloxy)-quinolin-2-yl]propane-1,3-diamine
• CAS No.: 913253-65-3
• Molecular Formula: C₂₁H₂₅N₃O₃
• Molecular Weight: 367.448
• Mol file: 913253-65-3.mol

Synonyms:2-methoxy-N'-[4-(4-methoxybenzyloxy)-quinolin-2-yl]propane-1,3-diamine

Chemical Property of 2-methoxy-N'-[4-(4-methoxybenzyloxy)-quinolin-2-yl]propane-1,3-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methoxy-N'-[4-(4-methoxybenzyloxy)-quinolin-2-yl]propane-1,3-diamine

There total 3 articles about 2-methoxy-N'-[4-(4-methoxybenzyloxy)-quinolin-2-yl]propane-1,3-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

2-methoxy-1,3-diaminopropane (44549-37-3) + 2-chloro-4-(4-methoxybenzyloxy)quinoline (733053-60-6) → 2-methoxy-N'-[4-(4-methoxybenzyloxy)-quinolin-2-yl]propane-1,3-diamine (913253-65-3)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 80 ℃; for 48h;

DOI:10.1016/j.bmc.2006.06.062

Reference yield:

2,4-dichloroquinoline (703-61-7) → 2-methoxy-N'-[4-(4-methoxybenzyloxy)-quinolin-2-yl]propane-1,3-diamine (913253-65-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / sodium hydride; 15-crown-5 / 20 °C

2: 51 percent / potassium carbonate / dimethylsulfoxide / 48 h / 80 °C

With 15-crown-5; sodium hydride; potassium carbonate; In dimethyl sulfoxide;

DOI:10.1016/j.bmc.2006.06.062

Reference yield:

aniline (62-53-3) → 2-methoxy-N'-[4-(4-methoxybenzyloxy)-quinolin-2-yl]propane-1,3-diamine (913253-65-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 55 percent / phosphorus oxychloride / Heating

2: 82 percent / sodium hydride; 15-crown-5 / 20 °C

3: 51 percent / potassium carbonate / dimethylsulfoxide / 48 h / 80 °C

With 15-crown-5; sodium hydride; potassium carbonate; trichlorophosphate; In dimethyl sulfoxide;

DOI:10.1016/j.bmc.2006.06.062

upstream raw materials:

2-methoxy-1,3-diaminopropane

2-chloro-4-(4-methoxybenzyloxy)quinoline

2,4-dichloroquinoline

aniline