(S)-Ethyl 3-(1-phenylethylamino)propanoate

Base Information

• Chemical Name: (S)-Ethyl 3-(1-phenylethylamino)propanoate
• CAS No.: 36940-65-5
• Molecular Formula: C₁₃H₁₉NO₂
• Molecular Weight: 221.299
• Mol file: 36940-65-5.mol

Synonyms:(S)-Ethyl 3-(1-phenylethylamino)propanoate

Chemical Property of (S)-Ethyl 3-(1-phenylethylamino)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-Ethyl 3-(1-phenylethylamino)propanoate

There total 5 articles about (S)-Ethyl 3-(1-phenylethylamino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

(S)-1-phenyl-ethylamine (2627-86-3) + ethyl acrylate (140-88-5,9003-32-1) → (S)-Ethyl 3-(1-phenylethylamino)propanoate (36940-65-5)

Guidance literature:

In ethanol; for 24h; Heating;

DOI:10.1002/(SICI)1099-1344(199602)38:2<105::AID-JLCR821>3.0.CO;2-X

Reference yield: 44.0%

ethyl acetate (141-78-6) + rac-methylbenzylamine (618-36-0) + ethyl acrylate (140-88-5,9003-32-1) → N-acetyl-1-phenylethylamine (36283-44-0,6284-14-6) + (S)-Ethyl 3-(1-phenylethylamino)propanoate (36940-65-5)

Guidance literature:

ethyl acetate; rac-methylbenzylamine; With Candida antarctica B lipase CAL-B acrylic resin; In toluene; at 50 ℃; for 72h; Enzymatic reaction;

ethyl acrylate; In toluene; at 50 ℃; for 72h; enantioselective reaction; Enzymatic reaction;

DOI:10.1002/ejoc.201500760

Reference yield:

acetophenone (98-86-2) → (S)-Ethyl 3-(1-phenylethylamino)propanoate (36940-65-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: formamide / water / 10 h / 210 °C

1.2: 1 h / 100 °C / Reflux

2.1: Candida antarctica B lipase CAL-B acrylic resin / toluene / 72 h / 50 °C / Enzymatic reaction

2.2: 72 h / 50 °C / Enzymatic reaction

With Candida antarctica B lipase CAL-B acrylic resin; formamide; In water; toluene; 2.2: |Michael Addition;

DOI:10.1002/ejoc.201500760

upstream raw materials:

(S)-1-phenyl-ethylamine

ethyl acrylate

ethyl N-(R)-α-methylbenzyl-3-aminopropionate

acetophenone

Downstream raw materials:

(S)-2-(2-chloro-2,2-dideuterioethyl)amino-3-((S)-α-methylbenzyl)-6,6-dideuteriotetrahydro-2H-1,3,2-oxazaphosphorin-2-oxide

N-(S)-α-methylbenzyl-1,1-dideuterio-3-aminopropan-1-ol