(1R,1S,2S)-(+)-2-<1-(2-hydroxy-1-phenylethyl)-1,2,3,6-tetrahydropyridin-2-yl>-1-phenylethanol

Base Information

Chemical Name:(1R,1S,2S)-(+)-2-<1-(2-hydroxy-1-phenylethyl)-1,2,3,6-tetrahydropyridin-2-yl>-1-phenylethanol
CAS No.:208832-13-7
Molecular Formula:C₂₁H₂₅NO₂
Molecular Weight:323.435
Hs Code.:

Synonyms:(1R,1S,2S)-(+)-2-<1-(2-hydroxy-1-phenylethyl)-1,2,3,6-tetrahydropyridin-2-yl>-1-phenylethanol

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Chemical Property of (1R,1S,2S)-(+)-2-<1-(2-hydroxy-1-phenylethyl)-1,2,3,6-tetrahydropyridin-2-yl>-1-phenylethanol

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Technology Process of (1R,1S,2S)-(+)-2-<1-(2-hydroxy-1-phenylethyl)-1,2,3,6-tetrahydropyridin-2-yl>-1-phenylethanol

There total 8 articles about (1R,1S,2S)-(+)-2-<1-(2-hydroxy-1-phenylethyl)-1,2,3,6-tetrahydropyridin-2-yl>-1-phenylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 237059-15-3
(R)-2-((S)-1-{(S)-2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-1-phenyl-ethyl}-1,2,3,6-tetrahydro-pyridin-2-yl)-1-phenyl-ethanol

: 208832-13-7
(1R,1S,2S)-(+)-2-<1-(2-hydroxy-1-phenylethyl)-1,2,3,6-tetrahydropyridin-2-yl>-1-phenylethanol

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; Ambient temperature;
DOI:10.1021/jo981912a

Reference yield:

: 100-59-4
phenylmagnesium chloride

: 208832-13-7
(1R,1S,2S)-(+)-2-<1-(2-hydroxy-1-phenylethyl)-1,2,3,6-tetrahydropyridin-2-yl>-1-phenylethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 32 percent / diethyl ether / Ambient temperature

2: 71 percent / aq. HCl / tetrahydrofuran / Ambient temperature

With hydrogenchloride; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jo981912a

Reference yield:

: 126366-29-8
(3S,8aS)-(+)-3-phenyl-2,3,8,8a-tetrahydro-5H-oxazolo<3,2-a>pyridine

: 208832-13-7
(1R,1S,2S)-(+)-2-<1-(2-hydroxy-1-phenylethyl)-1,2,3,6-tetrahydropyridin-2-yl>-1-phenylethanol

Guidance literature:: Multi-step reaction with 6 steps

1: 30 percent / diethyl ether / Ambient temperature

2: 90 percent / NEt₃, DMAP / CH₂Cl₂ / Ambient temperature

3: 89 percent / LiAlH₄ / tetrahydrofuran / Ambient temperature

4: 1.) DMSO, (COCl)2, 2.) NEt₃ / 1.) CH₂Cl₂, -78 deg C, 15 min, 2.) -78 deg C to room temperature

5: 32 percent / diethyl ether / Ambient temperature

6: 71 percent / aq. HCl / tetrahydrofuran / Ambient temperature

With hydrogenchloride; dmap; lithium aluminium tetrahydride; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jo981912a