Formamide, N-[3-(hydroxymethyl)phenyl]- (9CI)

Base Information

• Chemical Name: Formamide, N-[3-(hydroxymethyl)phenyl]- (9CI)
• CAS No.: 122488-77-1
• Molecular Formula: C8H9 N O2
• Molecular Weight: 151.165
• Mol file: 122488-77-1.mol

Synonyms:Formamide, N-[3-(hydroxymethyl)phenyl]- (9CI)

Chemical Property of Formamide, N-[3-(hydroxymethyl)phenyl]- (9CI)

Chemical Property:

• PSA: 49.33000
• LogP: 1.45610

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Formamide, N-[3-(hydroxymethyl)phenyl]- (9CI)

There total 3 articles about Formamide, N-[3-(hydroxymethyl)phenyl]- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

formic acid (64-18-6) + 3-Nitrobenzyl alcohol (619-25-0) → 3-formamidobenzyl alcohol (122488-77-1)

Guidance literature:

With palladium nanoparticles supported on magnetic reduced graphene oxide(at)CoAl-LDH catalyst; In toluene; at 70 ℃; for 3h; Sealed tube;

DOI:10.1002/aoc.6368

Reference yield: 63.0%

formic acid (64-18-6) + 3-aminobenzenemethanol (1877-77-6) → 3-formamidobenzyl alcohol (122488-77-1)

Guidance literature:

With tetraethoxy orthosilicate; In acetonitrile; at 25 ℃; for 17h; Inert atmosphere;

DOI:10.1016/j.tetlet.2017.01.056

Reference yield: 33.0%

3-aminobenzenemethanol (1877-77-6) + formic acid ethyl ester (109-94-4) → 3-formamidobenzyl alcohol (122488-77-1)

Guidance literature:

With ammonium hydroxide; 1.) 105 deg C, 3 d, steel bomb, 2.) methanol, RT, 5 h;

DOI:10.1021/jm00163a032

upstream raw materials:

3-aminobenzenemethanol

formic acid ethyl ester

formic acid

3-Nitrobenzyl alcohol

Downstream raw materials:

6-(dimethylamino)-9-(3-formamidobenzyl)-9H-purine

6-chloro-9-(3-formamidobenzyl)-9H-purine

6-chloro-7-(formamidobenzyl)-7H-purine

3-formamidobenzyl bromide

Refernces

• 1、 Nishikawa, Yasuhiro,Nakamura, Hidetsugu,Ukai, Norimitsu,Adachi, Wakana,Hara, Osamu. "Tetraethylorthosilicate as a mild dehydrating reagent for the synthesis of N-formamides with formic acid". supporting information. p. 860 - 863. Retrieved 2017/02/10.