1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-trifluoromethylisocarbostyril

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Chemical Name:1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-trifluoromethylisocarbostyril
CAS No.:374694-92-5
Molecular Formula:C₂₉H₂₀Cl₂F₃NO₆
Molecular Weight:606.382
Hs Code.:

Synonyms:1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-trifluoromethylisocarbostyril

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Chemical Property of 1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-trifluoromethylisocarbostyril

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Technology Process of 1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-trifluoromethylisocarbostyril

There total 4 articles about 1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-trifluoromethylisocarbostyril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1514-87-0
metyhyl chlorodifluoroacetate

: 374694-90-3
1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-iodoisocarbostyril

: 374694-92-5
1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-trifluoromethylisocarbostyril

Guidance literature:: With potassium fluoride; copper(l) iodide; In N,N-dimethyl-formamide; at 120 ℃; for 6h;
DOI:10.1081/NCN-100105246

Reference yield:

: 491-30-5
1-isoquinolone

: 374694-92-5
1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-trifluoromethylisocarbostyril

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,O-bis(trimethylsilyl)acetamide / acetonitrile / 0.5 h / 25 °C

1.2: 27 percent / SnCl₄ / acetonitrile / 0.5 h / 0 °C

2.1: 87 percent / ICl / CH₂Cl₂ / Heating

3.1: 71 percent / CuI; KF / dimethylformamide / 6 h / 120 °C

With potassium fluoride; copper(l) iodide; N,O-bis-(trimethylsilyl)-acetamide; Iodine monochloride; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1081/NCN-100105246

Reference yield:

: 21740-23-8
3,5-O-bis(4-chlorobenzoyl)-2-deoxy-α-D-ribofuranosyl chloride

: 374694-92-5
1-[3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-7-trifluoromethylisocarbostyril

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,O-bis(trimethylsilyl)acetamide / acetonitrile / 0.5 h / 25 °C

1.2: 27 percent / SnCl₄ / acetonitrile / 0.5 h / 0 °C

2.1: 87 percent / ICl / CH₂Cl₂ / Heating

3.1: 71 percent / CuI; KF / dimethylformamide / 6 h / 120 °C

With potassium fluoride; copper(l) iodide; N,O-bis-(trimethylsilyl)-acetamide; Iodine monochloride; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1081/NCN-100105246