(E)-3-(4-methoxyphenyl)-2-methyl-1-(3-methyl-1H-indol-1-yl)prop-2-en-1-one

Base Information

Chemical Name:(E)-3-(4-methoxyphenyl)-2-methyl-1-(3-methyl-1H-indol-1-yl)prop-2-en-1-one
CAS No.:1361029-46-0
Molecular Formula:C₂₀H₁₉NO₂
Molecular Weight:305.376
Hs Code.:

Synonyms:(E)-3-(4-methoxyphenyl)-2-methyl-1-(3-methyl-1H-indol-1-yl)prop-2-en-1-one

Suppliers and Price of (E)-3-(4-methoxyphenyl)-2-methyl-1-(3-methyl-1H-indol-1-yl)prop-2-en-1-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-3-(4-methoxyphenyl)-2-methyl-1-(3-methyl-1H-indol-1-yl)prop-2-en-1-one

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Technology Process of (E)-3-(4-methoxyphenyl)-2-methyl-1-(3-methyl-1H-indol-1-yl)prop-2-en-1-one

There total 2 articles about (E)-3-(4-methoxyphenyl)-2-methyl-1-(3-methyl-1H-indol-1-yl)prop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13048-81-2,40527-52-4,13048-80-1
(E)-3-(4-methoxyphenyl)-2-methylacrylic acid

: 1361029-46-0
(E)-3-(4-methoxyphenyl)-2-methyl-1-(3-methyl-1H-indol-1-yl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide

2.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane / 0.25 h / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

With oxalyl dichloride; tetra(n-butyl)ammonium hydrogensulfate; N,N-dimethyl-formamide; sodium hydroxide; In dichloromethane;
DOI:10.1002/anie.201106927

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 1361029-46-0
(E)-3-(4-methoxyphenyl)-2-methyl-1-(3-methyl-1H-indol-1-yl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride; phosphonic acid diethyl ester / 1,2-dimethoxyethane / 0 °C / Inert atmosphere

1.2: 1 h / 0 - 20 °C / Inert atmosphere

2.1: oxalyl dichloride; N,N-dimethyl-formamide

3.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane / 0.25 h / Inert atmosphere

3.2: 2 h / 20 °C / Inert atmosphere

With oxalyl dichloride; tetra(n-butyl)ammonium hydrogensulfate; sodium hydride; N,N-dimethyl-formamide; phosphonic acid diethyl ester; sodium hydroxide; In 1,2-dimethoxyethane; dichloromethane;
DOI:10.1002/anie.201106927

Reference yield: 61.0%

: 1361029-46-0
(E)-3-(4-methoxyphenyl)-2-methyl-1-(3-methyl-1H-indol-1-yl)prop-2-en-1-one

: 1361029-56-2
1-(4-methoxyphenyl)-2,9-dimethyl-3H-pyrrolo[1,2-a]indol-3-one

Guidance literature:: With pyridine-3-carbonitrile; oxygen; palladium diacetate; Trimethylacetic acid; In 1,3,5-trimethyl-benzene; at 110 ℃;
DOI:10.1002/anie.201106927