2,6-bis(5-phenyl-1H-pyrazol-3-yl)pyridine

Base Information

• Chemical Name: 2,6-bis(5-phenyl-1H-pyrazol-3-yl)pyridine
• CAS No.: 960594-76-7
• Molecular Formula: C₂₃H₁₇N₅
• Molecular Weight: 363.421
• Mol file: 960594-76-7.mol

Synonyms:2,6-bis(5-phenyl-1H-pyrazol-3-yl)pyridine

Chemical Property of 2,6-bis(5-phenyl-1H-pyrazol-3-yl)pyridine

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2,6-bis(5-phenyl-1H-pyrazol-3-yl)pyridine

There total 2 articles about 2,6-bis(5-phenyl-1H-pyrazol-3-yl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

3,3′-(pyridine-2,6-diyl)bis-(1-phenylpropane-1,3-dione) → 2,6-bis(5-diphenyl-1H-pyrazol-3-yl)pyridine (960594-76-7)

Guidance literature:

With hydrazine hydrate; In chloroform; for 1h; Reflux;

DOI:10.1007/s11164-016-2621-9

Reference yield:

2,6-bis(methoxycarbonyl)pyridine (5453-67-8) + acetophenone (98-86-2) → 2,6-bis(5-diphenyl-1H-pyrazol-3-yl)pyridine (960594-76-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium ethanolate / toluene / 18 h / Reflux

2: hydrazine; sulfuric acid / water; ethanol / 8 h / Reflux

With sulfuric acid; sodium ethanolate; hydrazine; In ethanol; water; toluene; 1: |Claisen Condensation / 2: |Knorr Pyrazole Synthesis;

DOI:10.1016/j.molstruc.2021.131147

Reference yield: 65.0%

2,6-bis(5-diphenyl-1H-pyrazol-3-yl)pyridine (960594-76-7) + zinc(II) sulfate heptahydrate + sulfuric acid (7664-93-9) → [Zn4(2,6-di-(5-phenyl-1H-pyrazol-3-yl)pyridine(-1H))4(μ4-SO4)][OH]2

Guidance literature:

In water; N,N-dimethyl-formamide; High Pressure; Zn salt, ligand in H2O/DMF were mixed; pH adjusted to 5-6 (aq. H2SO4); mixt. stirred for 4 h; sealed in Teflon lined stainless steel autoclave; heated under autogenous pressure at 160°C for 3 ds; slowly cooledto room temp.; filtered; washed (H2O); dried at room temp; elem. anal.;

DOI:10.1021/ic202678s

upstream raw materials:

2,6-bis(methoxycarbonyl)pyridine

acetophenone

Downstream raw materials:

di[(2-(5-phenyl-1H-pyrazol-3-yl)-6-(5-phenylpyrazol-3-yl)pyridine)(tri(p-trifluoromethylphenyl)phosphine)ruthenium(II)](μ-chloro) chloride

[Ag₂(2,6-bis(5-phenyl-1-pyrazol-3-yl)pyridine)2(6-(5-phenyl-1H-pyrazolyl-3-yl)picolinate)2]