[4-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)phenyl]phosphonic acid

Base Information

Chemical Name:[4-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)phenyl]phosphonic acid
CAS No.:1179329-43-1
Molecular Formula:C₂₆H₂₂F₅N₄O₆P
Molecular Weight:612.45
Hs Code.:

Synonyms:[4-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)phenyl]phosphonic acid

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Chemical Property of [4-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)phenyl]phosphonic acid

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Technology Process of [4-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)phenyl]phosphonic acid

There total 8 articles about [4-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)phenyl]phosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1179329-42-0
monoethyl [4-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)phenyl]phosphonate

: 1179329-43-1
[4-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)phenyl]phosphonic acid

Guidance literature:: With hydrogenchloride; water; In 1,4-dioxane; at 80 ℃; for 8h;

Reference yield:

: 76437-44-0
1-(bromomethyl)-4-fluoro-2-nitrobenzene

: 1179329-43-1
[4-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)phenyl]phosphonic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / acetonitrile

2.1: H3B*NMe3 / 20 % Pd(OH)2/C / methanol / 4 h / Reflux; Inert atmosphere

3.1: toluene; acetonitrile / 2 h / 75 - 80 °C / Inert atmosphere

3.2: 20 °C

4.1: potassium trimethylsilonate / tetrahydrofuran

5.1: hydrogenchloride; water / 1,4-dioxane / 8 h / 80 °C

With hydrogenchloride; H₃B*NMe₃; potassium trimethylsilonate; water; caesium carbonate; 20 % Pd(OH)2/C; In tetrahydrofuran; 1,4-dioxane; methanol; toluene; acetonitrile;

Reference yield:

: 20274-69-5
(4-fluoro-3-nitrophenyl)methanol

: 1179329-43-1
[4-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)phenyl]phosphonic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: phosphorus tribromide / dichloromethane / 20 °C

2.1: caesium carbonate / acetonitrile

3.1: H3B*NMe3 / 20 % Pd(OH)2/C / methanol / 4 h / Reflux; Inert atmosphere

4.1: toluene; acetonitrile / 2 h / 75 - 80 °C / Inert atmosphere

4.2: 20 °C

5.1: potassium trimethylsilonate / tetrahydrofuran

6.1: hydrogenchloride; water / 1,4-dioxane / 8 h / 80 °C

With hydrogenchloride; H₃B*NMe₃; potassium trimethylsilonate; water; phosphorus tribromide; caesium carbonate; 20 % Pd(OH)2/C; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene; acetonitrile;