monoethyl [4-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)phenyl]phosphonate

Base Information

Chemical Name:monoethyl [4-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)phenyl]phosphonate
CAS No.:1179329-42-0
Molecular Formula:C₂₈H₂₆F₅N₄O₆P
Molecular Weight:640.503
Hs Code.:

monoethyl [4-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)phenyl]phosphonate

Synonyms:monoethyl [4-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)phenyl]phosphonate

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Chemical Property of monoethyl [4-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)phenyl]phosphonate

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Technology Process of monoethyl [4-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)phenyl]phosphonate

There total 7 articles about monoethyl [4-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)phenyl]phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1179329-41-9
diethyl [4-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)phenyl]phosphonate

: 1179329-42-0
monoethyl [4-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)phenyl]phosphonate

Guidance literature:: With potassium trimethylsilonate; In tetrahydrofuran;

Reference yield:

: 76437-44-0
1-(bromomethyl)-4-fluoro-2-nitrobenzene

: 1179329-42-0
monoethyl [4-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)phenyl]phosphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / acetonitrile

2.1: H3B*NMe3 / 20 % Pd(OH)2/C / methanol / 4 h / Reflux; Inert atmosphere

3.1: toluene; acetonitrile / 2 h / 75 - 80 °C / Inert atmosphere

3.2: 20 °C

4.1: potassium trimethylsilonate / tetrahydrofuran

With H₃B*NMe₃; potassium trimethylsilonate; caesium carbonate; 20 % Pd(OH)2/C; In tetrahydrofuran; methanol; toluene; acetonitrile;

Reference yield:

: 20274-69-5
(4-fluoro-3-nitrophenyl)methanol

: 1179329-42-0
monoethyl [4-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)phenyl]phosphonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: phosphorus tribromide / dichloromethane / 20 °C

2.1: caesium carbonate / acetonitrile

3.1: H3B*NMe3 / 20 % Pd(OH)2/C / methanol / 4 h / Reflux; Inert atmosphere

4.1: toluene; acetonitrile / 2 h / 75 - 80 °C / Inert atmosphere

4.2: 20 °C

5.1: potassium trimethylsilonate / tetrahydrofuran

With H₃B*NMe₃; potassium trimethylsilonate; phosphorus tribromide; caesium carbonate; 20 % Pd(OH)2/C; In tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile;