(3R,4R)-4-(4-chlorophenyl)-3,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

Base Information

Chemical Name:(3R,4R)-4-(4-chlorophenyl)-3,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one
CAS No.:1380402-68-5
Molecular Formula:C₃₀H₂₄ClNO₃S
Molecular Weight:514.044
Hs Code.:

Synonyms:(3R,4R)-4-(4-chlorophenyl)-3,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4R)-4-(4-chlorophenyl)-3,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

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Technology Process of (3R,4R)-4-(4-chlorophenyl)-3,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

There total 4 articles about (3R,4R)-4-(4-chlorophenyl)-3,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103-82-2
phenylacetic acid

: 1116669-73-8
C₂₂H₁₈ClNO₂S

: 1380402-68-5
(3R,4R)-4-(4-chlorophenyl)-3,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

: C₃₀H₂₄ClNO₃S

Guidance literature:: With pivaloyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 2h; Overall yield = 74 %; stereoselective reaction;
DOI:10.1021/acscatal.5b02121

Reference yield:

: 63591-85-5
phenylacetic acid N-hydroxysuccinimide ester

: 1116669-73-8
C₂₂H₁₈ClNO₂S

: 1380402-68-5
(3R,4R)-4-(4-chlorophenyl)-3,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

: 4-(4-chlorophenyl)-3,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

: (3S,4S)-4-(4-chlorophenyl)-3,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

Guidance literature:: With (R)-5-benzyl-2-phenyl-6,7-dihydro-5H-pyrrplp[2,1-c][1,2,4]triazol-2-ium chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 10 ℃; for 24h; Overall yield = 82 %; stereoselective reaction; Inert atmosphere; Sealed tube;
DOI:10.1002/asia.201500959

Reference yield:

: 1380402-82-3
N-[(2E)-3-(4-chlorophenyl)-1-phenylprop-2-en-1-ylidene]-4-methylbenzenesulfonamide

: 864658-42-4
2,2-dimethylpropanoicphenylacetic anhydride

: 1380402-68-5
(3R,4R)-4-(4-chlorophenyl)-3,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

: 4-(4-chlorophenyl)-3,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

Guidance literature:: With (R)-(+)-2-phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃; for 2h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1002/anie.201109061