(+)-(1S,2S)-norcoronamic acid

Base Information

• Chemical Name: (+)-(1S,2S)-norcoronamic acid
• CAS No.: 98244-42-9
• Molecular Formula: C₅H₉NO₂
• Molecular Weight: 115.132
• DSSTox Substance ID: DTXSID90452418
• Nikkaji Number: J460.861E
• Wikidata: Q27159425
• Mol file: 98244-42-9.mol

Synonyms:(1S,2S)-1-amino-2-methylcyclopropane-1-carboxylic acid;norcoronamic acid

Chemical Property of (+)-(1S,2S)-norcoronamic acid

Chemical Property:

• PSA: 63.32000
• LogP: 0.50860
• XLogP3: -2.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 115.063328530
• Heavy Atom Count: 8
• Complexity: 134

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1CC1(C(=O)O)N
• Isomeric SMILES: C[C@H]1C[C@]1(C(=O)O)N

Technology Process of (+)-(1S,2S)-norcoronamic acid

There total 1 articles about (+)-(1S,2S)-norcoronamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

norcoronatine → (+)-coronafacic acid (62251-98-3) + (+)-(1S,2S)-norcoronamic acid (98244-42-9)

Guidance literature:

With hydrogenchloride; for 1h;

DOI:10.1016/S0031-9422(00)81049-3

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + (+)-(1S,2S)-norcoronamic acid (98244-42-9) → (1S,2S)-1-(N-(tert-butoxycarbonyl)amino)-2-methylcyclopropane-1-carboxylic acid (136378-33-1)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; for 8h; Ambient temperature;

DOI:10.1021/jo00030a009

Reference yield:

methanol (67-56-1) + (1R,2S- and 1S,2R)-2-methyl-1-aminocyclopropane-1-carboxylic acid (91366-06-2,93395-28-9,93395-29-0,93621-76-2,93621-77-3,98244-42-9,98244-43-0,98244-45-2,98302-67-1) → (Z)-1-amino-2-methylcyclopropanecarboxylic acid methyl ester hydrochloride (98259-91-7,138571-90-1,138663-12-4,138663-13-5,156258-66-1)

Guidance literature:

With hydrogenchloride; at 50 ℃; for 18h;

DOI:10.1016/S0040-4039(00)61918-4

Downstream raw materials:

(1S,2S)-1-(N-(tert-butoxycarbonyl)amino)-2-methylcyclopropane-1-carboxylic acid

(Z)-1-amino-2-methylcyclopropanecarboxylic acid methyl ester hydrochloride

(1R,2S)-1-((R)-2-Ethoxycarbonyloxy-2-phenyl-acetylamino)-2-methyl-cyclopropanecarboxylic acid methyl ester

(1R,2S)-1-((S)-2-Ethoxycarbonyloxy-2-phenyl-acetylamino)-2-methyl-cyclopropanecarboxylic acid methyl ester