N-(9-fluorenylmethoxycarbonyl)-7-O-(tert-butyldiphenylsilyl)-N-trityl morpholinocytidine

Base Information

Chemical Name:N-(9-fluorenylmethoxycarbonyl)-7-O-(tert-butyldiphenylsilyl)-N-trityl morpholinocytidine
CAS No.:1415645-62-3
Molecular Formula:C₅₉H₅₆N₄O₅Si
Molecular Weight:929.203
Hs Code.:

Synonyms:N-(9-fluorenylmethoxycarbonyl)-7-O-(tert-butyldiphenylsilyl)-N-trityl morpholinocytidine

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Chemical Property of N-(9-fluorenylmethoxycarbonyl)-7-O-(tert-butyldiphenylsilyl)-N-trityl morpholinocytidine

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Technology Process of N-(9-fluorenylmethoxycarbonyl)-7-O-(tert-butyldiphenylsilyl)-N-trityl morpholinocytidine

There total 4 articles about N-(9-fluorenylmethoxycarbonyl)-7-O-(tert-butyldiphenylsilyl)-N-trityl morpholinocytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 1415645-56-5
7-O-(tert-butyldiphenylsilyl)-N-trityl morpholinocytidine

: 1415645-62-3
N-(9-fluorenylmethoxycarbonyl)-7-O-(tert-butyldiphenylsilyl)-N-trityl morpholinocytidine

Guidance literature:: With triethylamine; In pyridine; at 0 - 20 ℃; for 3h; Molecular sieve; Inert atmosphere;
DOI:10.1080/15257770.2012.724491

Reference yield:

: 1415645-50-9
7-O-(tert-butyldiphenylsilyl)morpholinocytidine

: 1415645-62-3
N-(9-fluorenylmethoxycarbonyl)-7-O-(tert-butyldiphenylsilyl)-N-trityl morpholinocytidine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / N,N-dimethyl-formamide / 1 h / 0 °C / Molecular sieve; Inert atmosphere

2: triethylamine / pyridine / 3 h / 0 - 20 °C / Molecular sieve; Inert atmosphere

With triethylamine; In pyridine; N,N-dimethyl-formamide;
DOI:10.1080/15257770.2012.724491

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1415645-62-3
N-(9-fluorenylmethoxycarbonyl)-7-O-(tert-butyldiphenylsilyl)-N-trityl morpholinocytidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / pyridine / Molecular sieve; Inert atmosphere

2.1: sodium periodate; ammonium biborate tetrahydrate / methanol / 1.5 h / 20 °C / Molecular sieve; Inert atmosphere

2.2: 2 h / Molecular sieve; Inert atmosphere

3.1: triethylamine / N,N-dimethyl-formamide / 1 h / 0 °C / Molecular sieve; Inert atmosphere

4.1: triethylamine / pyridine / 3 h / 0 - 20 °C / Molecular sieve; Inert atmosphere

With 1H-imidazole; sodium periodate; ammonium biborate tetrahydrate; triethylamine; In pyridine; methanol; N,N-dimethyl-formamide;
DOI:10.1080/15257770.2012.724491