Technology Process of C23H18Cl2F3N3O4
There total 2 articles about C23H18Cl2F3N3O4 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-(3,4-dichlorophenoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid;
With
HOBt-6-carboxamidomethyl polystyrene; diisopropyl-carbodiimide;
dmap;
In
dichloromethane; N,N-dimethyl-formamide;
at 40 ℃;
for 12h;
methyl 4-(1-aminocyclopropyl)benzoate hydrochloride;
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane; N,N-dimethyl-formamide;
at 40 ℃;
for 12h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hexane; tetrahydrofuran; methanol / 12 h / 20 °C / Cooling with ice
2.1: hydrogenchloride / ethyl acetate; diethyl ether
3.1: diisopropyl-carbodiimide; HOBt-6-carboxamidomethyl polystyrene / dmap / dichloromethane; N,N-dimethyl-formamide / 12 h / 40 °C
3.2: 12 h / 40 °C
With
hydrogenchloride; HOBt-6-carboxamidomethyl polystyrene; diisopropyl-carbodiimide;
dmap;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
- Guidance literature:
-
C23H18Cl2F3N3O4;
With
lithium hydroxide;
In
1,4-dioxane;
at 60 - 140 ℃;
for 12.3333h;
Microwave irradiation;
With
hydrogenchloride;
In
1,4-dioxane; water;
