Ethyl 2-(phenylamino)-4-thiazolecarboxylate

Base Information

• Chemical Name: Ethyl 2-(phenylamino)-4-thiazolecarboxylate
• CAS No.: 126533-76-4
• Molecular Formula: C12H12 N2 O2 S
• Molecular Weight: 248.305
• Mol file: 126533-76-4.mol

Synonyms:Ethyl2-anilinothiazole-4-carboxylate

Chemical Property of Ethyl 2-(phenylamino)-4-thiazolecarboxylate

Chemical Property:

• Vapor Pressure: 4.67E-06mmHg at 25°C
• Melting Point: 138-141 °C
• Refractive Index: 1.629
• Boiling Point: 382.6°Cat760mmHg
• PKA: 2.05±0.10(Predicted)
• Flash Point: 185.2°C
• PSA: 82.69000
• Density: 1.289g/cm³
• LogP: 2.48530

Purity/Quality:

99% ^*data from raw suppliers

ethyl2-(phenylamino)-1,3-thiazole-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 2-(phenylamino)-4-thiazolecarboxylate

There total 10 articles about Ethyl 2-(phenylamino)-4-thiazolecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

ethyl Bromopyruvate (70-23-5) + monophenylthiourea (103-85-5) → ethyl 2-(N-phenylamino)thiazole-4-carboxylate (126533-76-4)

Guidance literature:

With sodium carbonate; In neat (no solvent); Milling;

DOI:10.1016/j.ejmech.2016.07.033

Reference yield:

ethyl Bromopyruvate (70-23-5) + sodium hydrogencarbonate (144-55-8) + monophenylthiourea (103-85-5) → ethyl 2-(N-phenylamino)thiazole-4-carboxylate (126533-76-4)

Guidance literature:

In ethanol;

Reference yield:

1-(4-methoxyphenyl)thiourea (2293-07-4) → ethyl 2-(N-phenylamino)thiazole-4-carboxylate (126533-76-4)

Guidance literature:

upstream raw materials:

ethyl Bromopyruvate

monophenylthiourea

sodium hydrogencarbonate

(4-fluoro-phenyl)-thiourea

Downstream raw materials:

(2-(phenylamino)thiazol-4-yl)(3,4,5-trimethoxyphenyl)methanone hydrochloride

(2-(phenylamino)thiazol-4-yl)(3,4,5-trimethoxyphenyl)methanone

N-methoxy-N-methyl-2-(phenylamino)thiazole-4-carboxamide

2-anilinothiazol-4-ylmethanol

Refernces

• 1、 Cheng, Xinlai,Yoshida, Hiroki,Raoofi, Dena,Saleh, Sawsan,Alborzinia, Hamed,Wenke, Frank,G?hring, Axel,Reuter, Stefanie,Mah, Nancy,Fuchs, Heiko,Andrade-Navarro, Miguel A.,Adjaye, James,Gul, Sheraz,Utikal, Jochen,Mrowka, Ralf,W?lfl, Stefan. "Ethyl 2-((4-Chlorophenyl)amino)thiazole-4-carboxylate and Derivatives Are Potent Inducers of Oct3/4". . p. 5742 - 5750. Retrieved 2015/08/24.
• 2、 -. "COMPOUNDS FOR TREATMENT OF CANCER". Paragraph 0039; 00339; 00340. . Retrieved 2011/10/03.