METHYL-PIPERIDIN-4-YLMETHYL-AMINE

Base Information

• Chemical Name: METHYL-PIPERIDIN-4-YLMETHYL-AMINE
• CAS No.: 126579-26-8
• Molecular Formula: C₇H₁₆N₂
• Molecular Weight: 128.217
• Hs Code.: 2933399090
• Mol file: 126579-26-8.mol

Synonyms:N-METHYL(PIPERIDIN-4-YL)METHANAMINE;METHYL-PIPERIDIN-4-YLMETHYL-AMINE

Chemical Property of METHYL-PIPERIDIN-4-YLMETHYL-AMINE

Chemical Property:

• Boiling Point: 178℃
• PKA: 10.57±0.10(Predicted)
• Flash Point: 58℃
• PSA: 24.06000
• Density: 0.861
• LogP: 0.92510

Purity/Quality:

97% ^*data from raw suppliers

N-Methyl-4-piperidinemethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL-PIPERIDIN-4-YLMETHYL-AMINE

There total 2 articles about METHYL-PIPERIDIN-4-YLMETHYL-AMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

piperidine-4-carboxylic acid methylamide (1903-69-1) → 4-(N-Methylaminomethyl)piperidine (126579-26-8)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; benzene; for 24h; Heating;

DOI:10.1021/jo00299a026

Reference yield:

N-methylisonicotinamide (6843-37-4) → 4-(N-Methylaminomethyl)piperidine (126579-26-8)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂, PtO₂ / acetic acid

2: 77 percent / LAH / diethyl ether; benzene / 24 h / Heating

With platinum(IV) oxide; lithium aluminium tetrahydride; hydrogen; In diethyl ether; acetic acid; benzene;

DOI:10.1021/jo00299a026

Reference yield:

butyl 4-[(2S)-5-tert-butoxy-2-([(4-chloro-6-phenylpyridin-2-yl)carbonyl]amino)-5-oxopentanoyl]piperazine-1-carboxylate (1214284-58-8) + 4-(N-Methylaminomethyl)piperidine (126579-26-8) → C37H54N6O6

Guidance literature:

With triethylamine; In dimethyl sulfoxide; at 100 ℃;

DOI:10.1016/j.bmcl.2009.12.110

upstream raw materials:

piperidine-4-carboxylic acid methylamide

N-methylisonicotinamide