3-Bromo-5-Chloro-2-Picoline

Base Information

• Chemical Name: 3-Bromo-5-Chloro-2-Picoline
• CAS No.: 131036-39-0
• Molecular Formula: C₆H₅BrClN
• Molecular Weight: 206.469
• Hs Code.: 2933399090
• Mol file: 131036-39-0.mol

Synonyms:3-Bromo-5-chloro-2-methylpyridine

Chemical Property of 3-Bromo-5-Chloro-2-Picoline

Chemical Property:

• PSA: 12.89000
• LogP: 2.80590
• Storage Temp.: 2-8°C

Purity/Quality:

97% purity ^*data from raw suppliers

3-Bromo-5-chloro-2-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Bromo-5-chloro-2-methylpyridine is a reagent in the picomolar inhibitors of HIV reverse transcriptase featuring bicyclic replacement of cyanovinylphenyl substructure.

Technology Process of 3-Bromo-5-Chloro-2-Picoline

There total 4 articles about 3-Bromo-5-Chloro-2-Picoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

dihydroxy-methyl-borane (13061-96-6) + 2,3-dibromo-5-chloro-pyridine (137628-17-2) → 3-bromo-5-chloro-2-methylpyridine (131036-39-0)

Guidance literature:

With potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; water; at 50 ℃; Reflux; Inert atmosphere;

Reference yield:

5-amino-3-bromo-2-methylpyridine (186593-43-1) → 3-bromo-5-chloro-2-methylpyridine (131036-39-0)

Guidance literature:

With copper(l) chloride; In acetonitrile; at 0 - 80 ℃; for 13h; Inert atmosphere;

Reference yield:

methylmagnesium bromide (75-16-1) + 2,3-dibromo-5-chloro-pyridine (137628-17-2) → 3-bromo-5-chloro-2-methylpyridine (131036-39-0)

Guidance literature:

With [1,1'-bis(diphenylphosphino)ferrocene]nickel(II) chloride; In tetrahydrofuran; at 0 ℃; for 4h;

upstream raw materials:

dihydroxy-methyl-borane

2,3-dibromo-5-chloro-pyridine

methylmagnesium bromide

5-amino-3-bromo-2-methylpyridine

Downstream raw materials:

5-chloro-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

3-bromo-5-chloropyridine-2-carbaldehyde

Refernces

• 1、 -. "2,6,7 SUBSTITUTED PURINES AS HDM2 INHIBITORS". Page/Page column 76. . Retrieved 2014/08/20.