2-CYANOPHENYLZINC BROMIDE

Base Information

• Chemical Name: 2-CYANOPHENYLZINC BROMIDE
• CAS No.: 131379-17-4
• Molecular Formula: C7H4BrNZn
• Molecular Weight: 247.409
• Mol file: 131379-17-4.mol

Synonyms:2-CYANOPHENYLZINC BROMIDE;2-CYANOPHENYLZINC BROMIDE, 0.5M SOLUTION IN TETRAHYDROFURAN;2-cyanophenylzinc bromide solution

Chemical Property of 2-CYANOPHENYLZINC BROMIDE

Chemical Property:

• Vapor Pressure: 0.524mmHg at 25°C
• Refractive Index: ">
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 23.79000
• Density: g/cm³
• LogP: 2.20158
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Cyanophenylzinc bromide solution 0.5 M in THF ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F,Xn
• Statements: 19-22-36/38-40-36/37-14-11
• Safety Statements: 16-26-33-36-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CYANOPHENYLZINC BROMIDE

There total 4 articles about 2-CYANOPHENYLZINC BROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

o-cyanobromobenzene (2042-37-7) + zinc (7440-66-6) → biphenyl-2,2'-dicarbonitrile (4341-02-0) + benzonitrile (100-47-0) + 2-cyanophenylzinc-bromide (131379-17-4)

Guidance literature:

With trifluoroacetic acid; cobalt(II) bromide; zinc dibromide; In acetonitrile; the mixt. in CH3CN was stirred at room temp., then arylbromide was added, stirred at room temp.; GC analysis;

DOI:10.1021/ja0289494

Reference yield: 65.0%

1-bromo-4-methoxy-benzene (104-92-7) + o-cyanobromobenzene (2042-37-7) → (4-methoxyphenyl)zinc(II) bromide (82303-13-7) + 2-cyanophenylzinc-bromide (131379-17-4)

Guidance literature:

With trifluoroacetic acid; cobalt(II) bromide; zinc dibromide; zinc; In hexanedinitrile; acetonitrile; Conversion of starting material;

Reference yield:

o-cyanobromobenzene (2042-37-7) + zinc (7440-66-6) → 2-cyanophenylzinc-bromide (131379-17-4)

Guidance literature:

In tetrahydrofuran; other Radiation; microwave-accelerated preparation of arylzinc bromide by Rieke zinc insertion into aryl bromide under sealed vessel conditions for 10 min; THF 180°C; HPLC or MS;

DOI:10.1039/b313887a

upstream raw materials:

1-bromo-4-methoxy-benzene

o-cyanobromobenzene

zinc

zinc dibromide

Downstream raw materials:

4-(2-Cyanophenyl)benzaldehyde

3-((2R)-5-(2-tert-butoxycarbonylamino-1-phenylpropan-2-yl)-1,3,4-oxadiazol-2-yl)-5-(2-(carbonitrile)phenyl)-N-methyl-N-(methylsulfonyl)benzenamine

C₃₉H₃₉N₃O₅

methyl 5-(5-{(1R)-1-[(tert-butoxycarbonyl)amino]-1-methyl-2-phenylethyl}-1,3,4-oxadiazol-2-yl)-2'-cyanobiphenyl-3-carboxylate