1N-BOC 4-(2'-METHYL-4'-NITROPHENOXY) PIPERIDINE

Base Information

• Chemical Name: 1N-BOC 4-(2'-METHYL-4'-NITROPHENOXY) PIPERIDINE
• CAS No.: 138227-68-6
• Molecular Formula: C17H24N2O5
• Molecular Weight: 336.388
• Hs Code.: 2933399090
• Mol file: 138227-68-6.mol

Synonyms:1N-BOC 4-(2'-METHYL-4'-NITROPHENOXY) PIPERIDINE;1-Boc-4-(2'-methyl-4'-nitrophenoxy)piperidine

Chemical Property of 1N-BOC 4-(2'-METHYL-4'-NITROPHENOXY) PIPERIDINE

Chemical Property:

• PSA: 84.59000
• LogP: 4.14260

Purity/Quality:

99.0%min ^*data from raw suppliers

tert-Butyl4-(2-methyl-4-nitrophenoxy)piperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1N-BOC 4-(2'-METHYL-4'-NITROPHENOXY) PIPERIDINE

There total 5 articles about 1N-BOC 4-(2'-METHYL-4'-NITROPHENOXY) PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-methyl-4-nitrophenol (99-53-6) + t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → 1-tert-butyloxycarbonyl-4-(4-nitro-2methylphenyloxy)piperidine (138227-68-6)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1248/cpb.56.758

Reference yield:

5-nitro-2-fluorotoluene (455-88-9) → 1-tert-butyloxycarbonyl-4-(4-nitro-2methylphenyloxy)piperidine (138227-68-6)

Guidance literature:

t-butyl 4-hydroxy piperidine-1-carboxylate; With sodium; In DMF (N,N-dimethyl-formamide); at 5 - 15 ℃; for 0.5h;

5-nitro-2-fluorotoluene; In DMF (N,N-dimethyl-formamide); at 5 - 20 ℃; for 3h;

Reference yield:

4-(4-nitro-2-methylphenyloxy)piperidine hydrochloride + di-tert-butyl dicarbonate (24424-99-5) → 1-tert-butyloxycarbonyl-4-(4-nitro-2methylphenyloxy)piperidine (138227-68-6)

Guidance literature:

With triethylamine; In dichloromethane; water;

upstream raw materials:

5-nitro-2-fluorotoluene

t-butyl 4-hydroxy piperidine-1-carboxylate

2-methyl-4-nitrophenol

diethylazodicarboxylate

Downstream raw materials:

1-tert-butyloxycarbonyl-4-(4-amino-2-methylphenyloxy)piperidine

C₂₁H₃₄N₂O₅Si

C₂₁H₃₄N₂O₅Si

C₂₆H₃₄N₄O₅

Refernces

• 1、 Lippa, Blaise,Kauffman, Goss S.,Arcari, Joel,Kwan, Tricia,Chen, Jinshan,Hungerford, William,Bhattacharya, Samit,Zhao, Xumiao,Williams, Courtney,Xiao, Jun,Pustilnik, Leslie,Su, Chunyan,Moyer, James D.,Ma, Ling,Campbell, Mary,Steyn, Stefanus. "The discovery of highly selective erbB2 (Her2) inhibitors for the treatment of cancer". . p. 3081 - 3086. Retrieved 2008/02/03.
• 2、 -. "BENZAMIDINE DERIVATIVE". Page 160. . Retrieved 2010/02/05.