5-Methoxy-2-(trimethylsilyl)pyridine

Base Information

Chemical Name:5-Methoxy-2-(trimethylsilyl)pyridine
CAS No.:139585-64-1
Molecular Formula:C9H15NOSi
Molecular Weight:181.307
Hs Code.:
DSSTox Substance ID:DTXSID10569476
Wikidata:Q82456634
Mol file:139585-64-1.mol

Synonyms:139585-64-1;5-Methoxy-2-(trimethylsilyl)pyridine;Pyridine, 5-methoxy-2-(trimethylsilyl)- (9CI);(5-methoxypyridin-2-yl)-trimethylsilane;SCHEMBL1511989;DTXSID10569476;SBMIKLWDMYSMSH-UHFFFAOYSA-N

Suppliers and Price of 5-Methoxy-2-(trimethylsilyl)pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 5-Methoxy-2-(trimethylsilyl)pyridine

Chemical Property:

PSA：22.12000
LogP:1.63540
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:181.092290636
Heavy Atom Count:12
Complexity:144

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CN=C(C=C1)[Si](C)(C)C

Technology Process of 5-Methoxy-2-(trimethylsilyl)pyridine

There total 4 articles about 5-Methoxy-2-(trimethylsilyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 75-77-4
chloro-trimethyl-silane

: 139585-48-1
2-chloro-5-methoxypyridine

: 139585-64-1
5-methoxy-2-(trimethylsilyl)pyridine

Guidance literature:: With iodine; magnesium; In tetrahydrofuran; at 70 ℃; for 1h;

Reference yield:

: 75-77-4
chloro-trimethyl-silane

: 105170-27-2
2-bromo-5-methoxypyridine

: 139585-64-1
5-methoxy-2-(trimethylsilyl)pyridine

Guidance literature:: 2-bromo-5-methoxypyridine; With n-butyllithium; In tetrahydrofuran; hexanes; at -78 ℃; for 0.5h;

chloro-trimethyl-silane; In tetrahydrofuran; hexanes; at -78 - 0 ℃; for 0.666667h;

Reference yield:

: 5350-93-6
6-Chloro-pyridin-3-ylamine

: 139585-64-1
5-methoxy-2-(trimethylsilyl)pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: NaNO₂, 1 N H₂SO₄, 2 N H₂SO₄

2: 32 percent / Na, methanol / dimethylsulfoxide

3: 19 percent / Mg, I₂ / tetrahydrofuran / 1 h / 70 °C

With methanol; sulfuric acid; iodine; sodium; magnesium; sodium nitrite; In tetrahydrofuran; dimethyl sulfoxide;