(+/-)-N-CBZ-2-methylproline

Base Information

Chemical Name:(+/-)-N-CBZ-2-methylproline
CAS No.:141870-95-3
Molecular Formula:C15H19 N O4
Molecular Weight:277.32
Hs Code.:2933990090
Mol file:141870-95-3.mol

Synonyms:1,2-Pyrrolidinedicarboxylicacid, 2-methyl-, 2-methyl 1-(phenylmethyl) ester, (?à)-

Suppliers and Price of (+/-)-N-CBZ-2-methylproline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
Methyl 1-Cbz-2-methylpyrrolidine-2-carboxylate
1 g
$ 493.00

Crysdot
1-Benzyl2-methyl2-methylpyrrolidine-1,2-dicarboxylate 95+%
5g
$ 627.00

Chemenu
1-Benzyl2-methyl2-methylpyrrolidine-1,2-dicarboxylate 95%
5g
$ 586.00

American Custom Chemicals Corporation
1-BENZYL-2-METHYL-2-METHYLPYRROLIDINE-1,2-DICARBOXYLATE 95.00%
5MG
$ 498.71

Alichem
1-Benzyl2-methyl2-methylpyrrolidine-1,2-dicarboxylate
5g
$ 620.73

AK Scientific
1-Benzyl2-methyl2-methylpyrrolidine-1,2-dicarboxylate
5g
$ 937.00

Total 9 raw suppliers

Chemical Property of (+/-)-N-CBZ-2-methylproline

Chemical Property:

PSA：66.84000
LogP:2.20020
Storage Temp.:2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl 1-Cbz-2-methylpyrrolidine-2-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (+/-)-N-CBZ-2-methylproline

There total 3 articles about (+/-)-N-CBZ-2-methylproline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1148-11-4
N-Benzyloxycarbonyl-L-proline

: 74-88-4
methyl iodide

: 141870-95-3
(+/-)-1-benzyl 2-methyl 2-methylpyrrolidine-1,2-dicarboxylate

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 - -20 ℃; for 3h;
DOI:10.1021/acschembio.8b00423

Reference yield: 96.0%

: 108645-62-1
N-benzyloxycarbonylproline methyl ester

: 74-88-4
methyl iodide

: 141870-95-3
(+/-)-1-benzyl 2-methyl 2-methylpyrrolidine-1,2-dicarboxylate

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; at -75 - -20 ℃; for 4h;

Reference yield:

: 63427-91-8
1-((benzyloxy)carbonyl)-2-methylpyrrolidine-2-carboxylic acid

: 74-88-4
methyl iodide

: 141870-95-3
(+/-)-1-benzyl 2-methyl 2-methylpyrrolidine-1,2-dicarboxylate

Guidance literature:: 1-((benzyloxy)carbonyl)-2-methylpyrrolidine-2-carboxylic acid; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at -78 - 20 ℃;