ALPHA,ALPHA-BIS(TRIMETHYLSILYL)-TERT-BUTYLKETIMINE

Base Information

• Chemical Name: ALPHA,ALPHA-BIS(TRIMETHYLSILYL)-TERT-BUTYLKETIMINE
• CAS No.: 147227-26-7
• Molecular Formula: C₁₃H₃₁NSi₂
• Molecular Weight: 257.567
• Hs Code.: 29310099
• Mol file: 147227-26-7.mol

Synonyms:ALPHA,ALPHA-BIS(TRIMETHYLSILYL)-TERT-BUTYLKETIMINE

Chemical Property of ALPHA,ALPHA-BIS(TRIMETHYLSILYL)-TERT-BUTYLKETIMINE

Chemical Property:

• Refractive Index: 1.4505-1.4525
• Boiling Point: 104 °C (8 mmHg)
• PSA: 23.85000
• LogP: 4.73780
• Storage Temp.: 0-6°C

Purity/Quality:

98%Min ^*data from raw suppliers

ALPHA,ALPHA-BIS(TRIMETHYLSILYL)-TERT-BUTYLKETIMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ALPHA,ALPHA-BIS(TRIMETHYLSILYL)-TERT-BUTYLKETIMINE

There total 2 articles about ALPHA,ALPHA-BIS(TRIMETHYLSILYL)-TERT-BUTYLKETIMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

chloro-trimethyl-silane (75-77-4) + N-(1-Methylethyliden)-tert-butylamin (66548-20-7) → α,α-bis(trimethylsilyl)-N-tert-butylacetimine (147227-26-7)

Guidance literature:

N-(1-Methylethyliden)-tert-butylamin; With lithium diisopropyl amide; In tetrahydrofuran; at -50 ℃; for 18h; Inert atmosphere;

chloro-trimethyl-silane; In tetrahydrofuran; at -50 - 20 ℃; Inert atmosphere;

DOI:10.1080/10426500903348039

Reference yield: 62.0%

chloro-trimethyl-silane (75-77-4) + α-(trimethylsilyl)-N-tert-butylacetimine → α,α-bis(trimethylsilyl)-N-tert-butylacetimine (147227-26-7)

Guidance literature:

α-(trimethylsilyl)-N-tert-butylacetimine; With lithium diisopropyl amide; In tetrahydrofuran; at -50 ℃; for 4h; Inert atmosphere;

chloro-trimethyl-silane; In tetrahydrofuran; at -50 - 20 ℃; Inert atmosphere;

DOI:10.1080/10426500903348039

Reference yield:

benzaldehyde (100-52-7) + α,α-bis(trimethylsilyl)-N-tert-butylacetimine (147227-26-7) → (Z)-4-phenylbut-3-en-2-one (937-53-1) + (E)-benzalacetone (1896-62-4)

Guidance literature:

With zinc(II) chloride; Yield given. Multistep reaction. Yields of byproduct given; 1) THF, 3 deg C, 2 h, 2) ether, water, RT, 1 h;

DOI:10.1021/jo00061a027

upstream raw materials:

chloro-trimethyl-silane

N-(1-Methylethyliden)-tert-butylamin

Downstream raw materials:

(Z)-4-phenylbut-3-en-2-one

(E)-benzalacetone

Refernces

• 1、 Bellassoued, Moncef,Majidi, Assieh. "A Simple and Highly Stereoselective Route to E-α,β-Unsaturated Aldehydes". . p. 2517 - 2522. Retrieved 2007/10/02.