2-CHLOROPHENYLZINC IODIDE

Base Information

• Chemical Name: 2-CHLOROPHENYLZINC IODIDE
• CAS No.: 148651-35-8
• Molecular Formula: C6H4 Cl I Zn
• Molecular Weight: 303.845
• Mol file: 148651-35-8.mol

Synonyms:2-Chlorophenylzinciodide

Chemical Property of 2-CHLOROPHENYLZINC IODIDE

Chemical Property:

• Refractive Index: ">
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 0.00000
• Density: g/cm³
• LogP: 3.02340
• Storage Temp.: 2-8°C
• Sensitive.: Air & Light Sensitive

Purity/Quality:

99% ^*data from raw suppliers

2-Chlorophenylzinc iodide solution 0.5M in THF ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F,Xn
• Statements: 11-19-22-36/37/38-40-36/37
• Safety Statements: 16-26-33-36-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Chlorophenylzinc iodide is an organozinc compound, which can be used as a reactant in Negishi cross-coupling reaction to construct carbon-carbon bonds by reacting with organic halides using nickel or palladium catalysts. It can also be utilized as a reactant to prepare: Arylmethanes via rhodium-catalyzed cross-coupling reaction with methyl halides. (2-chlorobenzyl)trimethylsilane by Rh-catalyzed cross-coupling reaction with (iodomethyl)trimethylsilane. Dichloro biphenyl by palladium catalyzed oxidative homocoupling reaction using N-chlorosuccinimide (NCS) or O2 as the oxidant.

Technology Process of 2-CHLOROPHENYLZINC IODIDE

There total 1 articles about 2-CHLOROPHENYLZINC IODIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-iodochlorobenzene (615-41-8) + zinc (7440-66-6) → 2-chlorophenylzinc iodide (148651-35-8)

Guidance literature:

With water; In further solvent(s); byproducts: C6H5Cl; Sonication; (N2); solvent = 1,1,3,3-tetramethylurea contg. water; 2 equivs. of Zn powder used; 30 °C, ultrasound applied for 8 h; 100% conversion; not isolated; conversion and yield detd. by quenching with I2;

DOI:10.1246/cl.1993.469

Reference yield: 86.0%

2-chlorophenylzinc iodide (148651-35-8) → 2,2'-Dichlorobiphenyl (13029-08-8)

Guidance literature:

With N-chloro-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In various solvent(s); at 35 - 45 ℃;

DOI:10.1246/bcsj.74.2415

Reference yield: 74.0%

benzyl bromide (100-39-0) + 2-chlorophenylzinc iodide (148651-35-8) → (o-benzyl)chlorobenzene (29921-41-3)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; chloro(1,5-cyclooctadiene)rhodium(I) dimer; at 80 ℃; for 24h;

DOI:10.1246/cl.1999.1241

upstream raw materials:

2-iodochlorobenzene

zinc

Downstream raw materials:

2-methoxymethylchlorobenzene

(o-benzyl)chlorobenzene

2-methylchlorobenzene

2,2'-Dichlorobiphenyl