1-(2-Amino-1-(4-methoxyphenyl)ethyl)cyclohexanol hydrochloride

Base Information

• Chemical Name: 1-(2-Amino-1-(4-methoxyphenyl)ethyl)cyclohexanol hydrochloride
• CAS No.: 149289-31-6
• Molecular Formula: C₁₅H₂₃NO₂
• Molecular Weight: 249.353
• European Community (EC) Number: 603-392-7,604-681-0
• UNII: O00PWS7DPA
• DSSTox Substance ID: DTXSID70893729
• Wikidata: Q27285135
• Mol file: 149289-31-6.mol

Synonyms:130198-05-9;1-(2-Amino-1-(4-methoxyphenyl)ethyl)cyclohexanol hydrochloride;1-[2-Amino-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride;149289-31-6;1-(4-Methoxyphenyl)-2-aminoethyl cyclohexanol hydrochloride;1-[2-Amino-1-(4-methoxyphenyl)-ethyl]-cyclohexanol hydrochloride;N,N-Didesmethylvenlafaxine hydrochloride;2-(4-Methoxyphenyl)-2-(1-hydroxycyclohexyl)ethylamine hydrochloride;UNII-O00PWS7DPA;O00PWS7DPA;1-[2-amino-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol;hydrochloride;N,N-Didesmethylvenlafaxine hydrochloride, (+/-)-;MFCD06658143;1-(2-Amino-1-(p-methoxyphenyl)ethyl)cyclohexanol hydrochloride;1-[2-amino-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol Hydrochloride;Cyclohexanol, 1-[2-amino-1-(4-methoxyphenyl)ethyl]-, hydrochloride;Cyclohexanol, 1-(2-amino-1-(4-methoxyphenyl)ethyl)-, hydrochloride (1:1);EC 603-392-7;1-(4-Methoxyphenyl)-2-aminoethyl cyclohexanol HCl;1-[2-amino-1-(4-methoxy phenyl)ethyl]cyclohexanol hydrochloride;1-[(1RS)-2-Amino-1-(4-methoxyphenyl)ethyl]cyclohexanol Hydrochloride;Cyclohexanol, 1-[2-amino-1-(4-methoxyphenyl)ethyl]-, hydrochloride (1:1);1-(2-Amino-1-(4-methoxyphenyl)ethyl)cyclohexanol HCl;1-[2-AMINO-1-(4-METHOXYPHENYL)ETHYL]CYCLOHEXANOL HCl;1-(2-Amino-1-(4-methoxyphenyl)ethyl)cyclohexan-1-ol hydrochloride;Venlafaxine Hydrochloride Imp. C (EP);Venlafaxine Imp. C (EP);Venlafaxine Hydrochloride Imp. C (EP) as Hydrochloride;Venlafaxine Hydrochloride Impurity C as Hydrochloride;Venlafaxine Impurity C as Hydrochloride;1-[2-Amino-1-(4-methoxyphenyl)ethyl]cyclohexanol.HCl;SCHEMBL3325847;1-[2-Amino-1-(4-methyoxyphenyl)ethyl]cyclohexanol.HCl;DTXSID70893729;NTKXIDDUCSFBBF-UHFFFAOYSA-N;1-(2-AMINO-1-(4-METHOXYPHENYL)ETHYL) CYCLOHEXANOL HCL;BCP09340;AKOS015888208;AC-7776;CS-O-31492;SB82214;AS-11903;SY037120;AM20020381;CS-0150413;FT-0643123;FT-0643435;EC 700-023-2;A806037;Q-100118;Q27285135;1-[2-Amino-1-(4-methyoxyphenyl)ethyl]cyclohexanol HCl;1-[2-(Amino)-1-(4-methoxyphenyl)ethyl]cyclohexanol Hydrochloride;1-[2-Amino-1-(4-methoxyphenyl)-ethyl]cyclohexanol hydrochloride;1-[2-amino-1-(4-methoxyphenyl)ethyl]-cyclohexanol hydrochloride;2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl ammonium chloride;Venlafaxine Hydrochloride Imp. C (EP) as Hydrochloride: 1-[(1RS)-2-Amino-1-(4-methoxyphenyl)ethyl]cyclo-hexanol Hydrochloride

Chemical Property of 1-(2-Amino-1-(4-methoxyphenyl)ethyl)cyclohexanol hydrochloride

Chemical Property:

• Melting Point: 172-180°C
• Boiling Point: 394.608 °C at 760 mmHg
• Flash Point: 192.452 °C
• PSA: 55.48000
• Density: 1.108 g/cm³
• LogP: 3.93500
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 285.1495567
• Heavy Atom Count: 19
• Complexity: 243

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(CN)C2(CCCCC2)O.Cl

Technology Process of 1-(2-Amino-1-(4-methoxyphenyl)ethyl)cyclohexanol hydrochloride

There total 15 articles about 1-(2-Amino-1-(4-methoxyphenyl)ethyl)cyclohexanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-[cyano(4-methoxyphenyl)methyl]cyclohexanol (93413-76-4,131801-69-9) → N,N-didesmethylvenlafaxine (93413-77-5,272788-06-4,273720-73-3,149289-31-6)

Guidance literature:

With lithium aluminium tetrahydride; aluminium trichloride;

DOI:10.1016/j.tetlet.2004.08.018

Reference yield: 100.0%

1-[2-amino-1-(4-methoxyphenyl)ethyl]cyclohexanol methanesulfonate salt (1204232-46-1) → N,N-didesmethylvenlafaxine (93413-77-5,272788-06-4,273720-73-3,149289-31-6)

Guidance literature:

With ammonia; In water; ethyl acetate; at 20 ℃; for 0.166667h; pH=9;

Reference yield: 83.6%

ammonium hydroxide (1336-21-6) + cobalt chloride + 1-[cyano(4-methoxyphenyl)methyl]cyclohexanol (93413-76-4,131801-69-9) → N,N-didesmethylvenlafaxine (93413-77-5,272788-06-4,273720-73-3,149289-31-6)

Guidance literature:

With hydrogenchloride; sodium borohydrid; In methanol; water; ethyl acetate;

upstream raw materials:

1-[cyano(4-methoxyphenyl)methyl]cyclohexanol

cyclohexanone

p-methoxybenzylnitrile

cyclohexanol

Downstream raw materials:

N-Desmethylvenlafaxine hydrochloride

N-Desmethylvenlafaxine

1-[2-dimethylamino-1-(4-methoxyphenyl)ethyl]cyclohexanol