150698-79-6

Basic information

• Product Name: 1-(3-bromo-4-fluorophenyl)-2,2,2-trifluoroethanol
• Synonyms: 1-(3-bromo-4-fluorophenyl)-2,2,2-trifluoroethanol
• CAS NO: 150698-79-6
• Molecular Weight: 273.025
• Mol File: 150698-79-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(3-bromo-4-fluorophenyl)-2,2,2-trifluoroethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-bromo-4-fluorophenyl)-2,2,2-trifluoroethanol(150698-79-6)
• EPA Substance Registry System: 1-(3-bromo-4-fluorophenyl)-2,2,2-trifluoroethanol(150698-79-6)

Safety Data

• Hazardous Substances Data: 150698-79-6(Hazardous Substances Data)

Upstream product

• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 77771-02-9 3-bromo-4-fluorobenzaldehyde 

Downstream Products

• 150698-74-1 2,2,2-trifluoro-3'-bromo-4’-fluoroacetophenone 

Relevant articles and documents

Diversity-oriented approach to CF3CHF-, CF3CFBr-, CF3CF2-, (CF3)2CH-, and CF3(SCF3)CH-substituted arenes from 1-(Diazo-2,2,2-trifluoroethyl)arenes

Arenes substituted with perfluoroalkyl groups are attractive targets for drug and agrochemical development. Exploiting the carbenic character of donor/acceptor diazo compounds, a diversity-oriented synthesis of perfluoroalkylated arenes, for late stage fluorofunctionalization, is described. The reaction of 1-(diazo-2,2,2-trifluoroethyl)arenes with HF, F/Br, F2, CF3H, and CF3SH sources give direct access to a variety of perfluoroalkyl-substituted arenes presenting with incremental fluorine content. The value of this approach is also demonstrated for radiochemistry and positron emission tomography with the [18F]-labeling of CF3CHF-, CF3CBrF-, and CF3CF2-arenes from [18F]fluoride.