4-Bromo-3'-methoxybenzophenone

Base Information

• Chemical Name: 4-Bromo-3'-methoxybenzophenone
• CAS No.: 151239-47-3
• Molecular Formula: C14H11 Br O2
• Molecular Weight: 291.144
• Hs Code.: 2914700090
• European Community (EC) Number: 889-801-1
• DSSTox Substance ID: DTXSID20373708
• Nikkaji Number: J2.258.240B
• Wikidata: Q82162008
• Mol file: 151239-47-3.mol

Synonyms:151239-47-3;4-Bromo-3'-methoxybenzophenone;(4-bromophenyl)(3-methoxyphenyl)methanone;(4-bromophenyl)-(3-methoxyphenyl)methanone;4-Bromo-3/'-methoxybenzophenone;SCHEMBL3468157;3-Methoxy-4'-bromobenzophenone;DTXSID20373708;XKJUSMRRMJSDMQ-UHFFFAOYSA-N;BGA23947;MFCD01311563;AKOS009339767;AC-30755;CS-0337120;FT-0643470;(4-Bromo-phenyl)-(3-methoxy-phenyl)-methanone

Chemical Property of 4-Bromo-3'-methoxybenzophenone

Chemical Property:

• Refractive Index: 1.593
• Boiling Point: 396.8°Cat760mmHg
• Flash Point: 193.8°C
• PSA: 26.30000
• Density: 1.401g/cm³
• LogP: 3.68870
• XLogP3: 4.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 289.99424
• Heavy Atom Count: 17
• Complexity: 259

Purity/Quality:

98%min ^*data from raw suppliers

4-bromo-3'-methoxybenzophenone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC(=C1)C(=O)C2=CC=C(C=C2)Br

Technology Process of 4-Bromo-3'-methoxybenzophenone

There total 9 articles about 4-Bromo-3'-methoxybenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(4-bromo-phenyl)-(3-methoxy-phenyl)-methanol (134446-26-7) → (4-bromophenyl)-(3-methoxyphenyl)-methanone (151239-47-3)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; at 60 ℃;

DOI:10.1016/j.ejmech.2011.09.004

Reference yield: 86.0%

(3-methoxyphenyl)magnesium bromide (36282-40-3) + 4-chlorobenzoyl chloride (586-75-4) → (4-bromophenyl)-(3-methoxyphenyl)-methanone (151239-47-3)

Guidance literature:

4-chlorobenzoyl chloride; With tributylphosphine; In tetrahydrofuran; at -20 ℃; for 0.366667h; Schlenk technique; Inert atmosphere;

(3-methoxyphenyl)magnesium bromide; In tetrahydrofuran; at 20 ℃; for 0.5h; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.ejmech.2021.113930

Reference yield: 80.0%

m-anisoyl chloride (1711-05-3) + 4-bromophenylmagnesium iodide (872088-07-8) → (4-bromophenyl)-(3-methoxyphenyl)-methanone (151239-47-3)

Guidance literature:

With Bis<2-(N,N-dimethylamino)aethyl>aether; In tetrahydrofuran; cooling;

DOI:10.1021/ol052150q

upstream raw materials:

m-anisoyl chloride

4-bromophenylmagnesium iodide

(4-bromo-phenyl)-(3-methoxy-phenyl)-methanol

(3-methoxyphenyl)magnesium bromide

Downstream raw materials:

2-amino-1-(4-bromo-phenyl)-1-(3-methoxy-phenyl)-ethanol

(4'-hydroxy-3'-methylbiphenyl-4-yl)-(3-hydroxyphenyl)-methanone

(3'-fluoro-4'-hydroxybiphenyl-4-yl)-(3-hydroxyphenyl)-methanone

(2'-chloro-4'-hydroxybiphenyl-4-yl)-(3-hydroxyphenyl)-methanone