134446-26-7

Basic information

• Product Name: Benzenemethanol, a-(4-bromophenyl)-3-methoxy-
• Synonyms: (4-bromophenyl)-(3-methoxyphenyl)-methanol;(4-bromophenyl)(3-methoxyphenyl)methanol;(4-bromophenyl)(3-methoxyphenyl)-methanol
• CAS NO: 134446-26-7
• Molecular Formula: C14H13BrO2
• Molecular Weight: 293.16
• Mol File: 134446-26-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, a-(4-bromophenyl)-3-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, a-(4-bromophenyl)-3-methoxy-(134446-26-7)
• EPA Substance Registry System: Benzenemethanol, a-(4-bromophenyl)-3-methoxy-(134446-26-7)

Safety Data

• Hazardous Substances Data: 134446-26-7(Hazardous Substances Data)

Upstream product

• 2845-89-8 1-chloro-3-methoxy-benzene 
• 1122-91-4 4-bromo-benzaldehyde 
• 578-57-4 2-bromoanisole 
• 36282-40-3 (3-methoxyphenyl)magnesium bromide 

Downstream Products

• 151239-47-3 (4-bromophenyl)-(3-methoxyphenyl)-methanone 
• 134446-27-8 (+/-)-4-Bromo-α-(3-methoxybenzene)benzyl Chloride 
• 1357563-62-2 (4'-methoxy-3'-methylbiphenyl-4-yl)-(3-methoxyphenyl)-methanone 
• 1357563-33-7 (4'-hydroxy-3'-methylbiphenyl-4-yl)-(3-hydroxyphenyl)-methanone 
• 1357563-63-3 (3'-fluoro-4'-methoxybiphenyl-4-yl)-(3-methoxyphenyl)-methanone 
• 1357563-34-8 (3'-fluoro-4'-hydroxybiphenyl-4-yl)-(3-hydroxyphenyl)-methanone 
• 1357563-65-5 (2'-chloro-4'-methoxybiphenyl-4-yl)-(3-methoxyphenyl)-methanone 
• 1357563-35-9 (2'-chloro-4'-hydroxybiphenyl-4-yl)-(3-hydroxyphenyl)-methanone 
• 1357563-67-7 (3'-chloro-4'-hydroxybiphenyl-4-yl)-(3-methoxyphenyl)-methanone 
• 1357563-36-0 (3'-chloro-4'-hydroxybiphenyl-4-yl)-(3-hydroxyphenyl)-methanone 

Relevant articles and documents

Expedient Preparation of Aryllithium and Arylzinc Reagents from Aryl Chlorides Using Lithium 4,4′-Di- tert -Butylbiphenylide and Zinc(II) Chloride

We report an efficient method for the preparation of aryllithium and zinc reagents from inexpensive and readily available aryl chlorides by using lithium 4,4′-di-tert-butylbiphenylide (LiDBB) as a lithiation reagent. The resulting organometallic reagents underwent subsequent reactions with a variety of electrophiles, such as an aldehydes, DMF, PhSSO2Ph, TsCN, an aryl halide, or an acid chloride (through Pd-catalyzed cross-coupling). Aryl chlorides bearing substituents, including methoxy, 3,4-methylenedioxy, fluoride, TMS, OTMS, NMe2, acetal, and ketal, were shown to be appropriate substrates. Interestingly, aryl chlorides containing a formyl group could also be used, provided that the formyl group was temporarily converted into an α-amino alkoxide by using the lithium amide of N,N,N′-trimethylethylenediamine (LiTMDA). The presence of a hydroxyl group was also tolerated when it was deprotonated with n-BuLi prior to the addition of LiDBB.

3,3-biarylpiperidine and 2,2-biarylmorpholine derivatives

The present invention relates to compounds of the formula I, wherein Z1, Z2, X, Q, R1, R2and R3are defined as in the specification, pharmaceutical compositions containing such compounds the use of suc