Pyrrolidine, 1-(trifluoroacetyl)- (7CI,8CI,9CI)

Base Information

• Chemical Name: Pyrrolidine, 1-(trifluoroacetyl)- (7CI,8CI,9CI)
• CAS No.: 6442-87-1
• Molecular Formula: C6H8 F3 N O
• Molecular Weight: 167.131
• Mol file: 6442-87-1.mol

Synonyms:Pyrrolidine,1-(trifluoroacetyl)- (7CI,8CI,9CI); N-Trifluoroacetylpyrrolidine

Chemical Property of Pyrrolidine, 1-(trifluoroacetyl)- (7CI,8CI,9CI)

Chemical Property:

• PSA: 20.31000
• LogP: 1.10900

Purity/Quality:

1-(TRIFLUOROACETYL)-PYRROLIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrrolidine, 1-(trifluoroacetyl)- (7CI,8CI,9CI)

There total 7 articles about Pyrrolidine, 1-(trifluoroacetyl)- (7CI,8CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

pyrrolidine (123-75-1) + ethyl trifluoroacetate, (383-63-1) → 2,2,2-trifluoro-1-pyrrolidin-1-ylethanone (6442-87-1)

Guidance literature:

for 16h; Ambient temperature;

DOI:10.1002/prac.199733901128

Reference yield: 60.0%

(-)-N-(trifluoroacetyl)prolyl chloride (92076-92-1) → 2,2,2-trifluoro-1-pyrrolidin-1-ylethanone (6442-87-1)

Guidance literature:

With samarium diiodide; In tetrahydrofuran; Ambient temperature;

DOI:10.1016/S0040-4039(00)79575-X

Reference yield: 54.0%

pyrrolidine (123-75-1) + trifluoroacetic anhydride (407-25-0) → 2,2,2-trifluoro-1-pyrrolidin-1-ylethanone (6442-87-1) + pyrrolidinium 2,2,2-trifluoroacetate

Guidance literature:

In diethyl ether; at 20 ℃; for 0.5h;

DOI:10.1021/jp027696y

upstream raw materials:

(-)-N-(trifluoroacetyl)prolyl chloride

pyrrolidine

ethyl trifluoroacetate,

trifluoroacetic anhydride

Downstream raw materials:

1-phenyl-2,2,2-trifluoromethylethanol

2,2,2-trifluoro-1-(4-isopropylphenyl)ethan-1-one