(2,6-Dimethylpyridin-3-yl)methanol

Base Information

• Chemical Name: (2,6-Dimethylpyridin-3-yl)methanol
• CAS No.: 582303-10-4
• Molecular Formula: C8H11NO
• Molecular Weight: 137.181
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID20382810
• Wikidata: Q82174254
• Mol file: 582303-10-4.mol

Synonyms:(2,6-dimethylpyridin-3-yl)methanol;582303-10-4;(2,6-Dimethyl-pyridin-3-yl)-methanol;(2,6-dimethyl-3-pyridinyl)methanol;SCHEMBL957406;DTXSID20382810;AGGDOLFSEUKNKM-UHFFFAOYSA-N;MFCD03265779;AKOS012126048;(2,6-dimethyl-pyridine-3-yl)methanol;SB37790;3-Pyridinemethanol,2,6-dimethyl-(9CI);5-(hydroxymethyl)-2,6-dimethyl-pyridine;TS-01775;CS-0103511;FT-0690259;F12480

Chemical Property of (2,6-Dimethylpyridin-3-yl)methanol

Chemical Property:

• Boiling Point: 245.4±35.0 °C(Predicted)
• PKA: 13.73±0.10(Predicted)
• PSA: 33.12000
• Density: 1.063±0.06 g/cm3(Predicted)
• LogP: 1.19070
• Storage Temp.: 2-8°C
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 137.084063974
• Heavy Atom Count: 10
• Complexity: 105

Purity/Quality:

97% ^*data from raw suppliers

(2,6-dimethylpyridin-3-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC(=C(C=C1)CO)C

Technology Process of (2,6-Dimethylpyridin-3-yl)methanol

There total 2 articles about (2,6-Dimethylpyridin-3-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl 2,6-dimethylnicotinate (1721-13-7) → (2,6-dimethylpyridin-3-yl)methanol (582303-10-4)

Guidance literature:

ethyl 2,6-dimethylnicotinate; With lithium aluminium tetrahydride; In diethyl ether; at 55 ℃; for 1.5h; Heating / reflux;

With water; In diethyl ether; at 0 ℃; for 1h;

Reference yield:

ethyl 4-chloro-2,6-dimethylnicotinate (70271-80-6) → (2,6-dimethylpyridin-3-yl)methanol (582303-10-4)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium/CaCO₃; methanol / Hydrogenation

2: lithium alanate; diethyl ether / und anschliessenden Erwaermen_.

With methanol; Lindlar's catalyst; lithium aluminium tetrahydride; diethyl ether;

Reference yield:

(2,6-dimethylpyridin-3-yl)methanol (582303-10-4) → 2,6-dimethylpyridine-3-carboxaldehyde (650141-20-1)

Guidance literature:

With pyridine; chromium(VI) oxide; Heating;

DOI:10.1021/jm00123a012

upstream raw materials:

ethyl 2,6-dimethylnicotinate

ethyl 4-chloro-2,6-dimethylnicotinate

Downstream raw materials:

2,6-dimethylpyridine-3-carboxaldehyde

(E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-(2,6-dimethyl-pyridin-3-yl)-acrylamide

2,3,6-trimethylpyridine

(2,6-dimethylpyridin-3-yl)methanamine