1721-13-7Relevant articles and documents
A new one-pot three-component condensation reaction for the synthesis of 2,3,4,6-tetrasubstituted pyridines
Bagley, Mark C.,Dale, James W.,Bower, Justin
, p. 1682 - 1683 (2002)
The one-pot three-component condensation of a β-ketoester, ammonia and an alkynone in the presence of a Bronsted or Lewis acid or Amberlyst 15 ion exchange resin provided 2,3,6-trisubstituted or 2,3,4,6-tetrasubstituted pyridines directly in good yield and with total regiocontrol.
Synthesis of pyridines and pyrido[2,3-d]pyrimidines by the Lewis acid catalysed Bohlmann-Rahtz heteroannulation reaction
Bagley,Dale,Hughes,Ohnesorge,Phillips,Bower
, p. 1523 - 1526 (2001)
Lewis acids catalyse the Bohlmann-Rahtz heteroannulation reaction to generate highly functionalised pyridines from enamino esters and alkynones in a single synthetic step. Of the catalysts studied, ytterbium(III) trifluoromethanesulfonate and zinc(II) bromide are the two most efficient for the synthesis of pyridines and pyrido[2,3-d]pyrimidines, from ethyl β-aminocrotonate or 2,6-di-aminopyrimidin-4-one respectively, in up to 94% yield.
Bohlmann-Rahtz cyclodehydration of aminodienones to pyridines using N-iodosuccinimide
Bagley, Mark C.,Glover, Christian
experimental part, p. 3211 - 3227 (2010/09/04)
Cyclodehydration of Bohlmann-Rahtz aminodienone intermediates using N-iodosuccinimide as a Lewis acid proceeds at low temperature under very mild conditions to give the corresponding 2, 3,6-trisubstituted pyridines in high yield and with total regiocontrol.
One-pot multistep Bohlmann-Rahtz heteroannulation reactions: Synthesis of dimethyl sulfomycinamate
Bagley, Mark C.,Chapaneri, Krishna,Dale, James W.,Xiong, Xin,Bower, Justin
, p. 1389 - 1399 (2007/10/03)
(Chemical Equation Presented) The synthesis of dimethyl sulfomycinamate, the acidic methanolysis product of the sulfomycin family of thiopeptide antibiotics, from methyl 2-oxo-4-(trimethylsilyl)but-3-ynoate is achieved in a 2,3,6-trisubstituted pyridine synthesis that proceeds with total regiocontrol in 13 steps by the Bohlmann-Rahtz heteroannulation of a 1-(oxazol-4-yl)enamine or in 12 steps and 9% yield by three-component cyclocondensation with N-[3-oxo-3-(oxazol-4-yl)propanoyl]serine and ammonia in ethanol.