(S)-4-(2-OXO-4-PHENYLOXAZOLIDIN-3-YL)-N-PROPYLBENZAMIDE

Base Information

• Chemical Name: (S)-4-(2-OXO-4-PHENYLOXAZOLIDIN-3-YL)-N-PROPYLBENZAMIDE
• CAS No.: 572923-17-2
• Molecular Formula: C19H20N2O3
• Molecular Weight: 324.379
• Mol file: 572923-17-2.mol

Synonyms:(S)-4-(2-OXO-4-PHENYLOXAZOLIDIN-3-YL)-N-PROPYLBENZAMIDE

Chemical Property of (S)-4-(2-OXO-4-PHENYLOXAZOLIDIN-3-YL)-N-PROPYLBENZAMIDE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.591
• Boiling Point: 528.369°C at 760 mmHg
• PKA: 15.16±0.46(Predicted)
• Flash Point: 273.348°C
• PSA: 58.64000
• Density: 1.206g/cm³
• LogP: 3.98020

Purity/Quality:

99%min ^*data from raw suppliers

(S)-4-(2-OXO-4-PHENYLOXAZOLIDIN-3-YL)-N-PROPYLBENZAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-4-(2-OXO-4-PHENYLOXAZOLIDIN-3-YL)-N-PROPYLBENZAMIDE

There total 3 articles about (S)-4-(2-OXO-4-PHENYLOXAZOLIDIN-3-YL)-N-PROPYLBENZAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-chloro-N-n-propylbenzamide (7461-32-7) + (S)-4-phenyl-2-oxazolidinone (99395-88-7,7480-32-2) → 4-(4-phenyl-2-oxo-oxazolidin-3-yl)-N-propyl-benzamide (572923-17-2)

Guidance literature:

With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; caesium carbonate; johnphos; In toluene; at 115 ℃; for 18h;

DOI:10.1021/ol034428p

Reference yield: 97.0%

(S)-4-phenyl-2-oxazolidinone (99395-88-7,7480-32-2) + 4-bromo-N-(propyl)benzamide (223557-19-5) → 4-(4-phenyl-2-oxo-oxazolidin-3-yl)-N-propyl-benzamide (572923-17-2)

Guidance literature:

With copper(l) iodide; potassium carbonate; rac-diaminocyclohexane; In 1,4-dioxane; Heating;

DOI:10.1021/jo052060z

Reference yield:

4-iodo-N-propyl-benzamide (39887-30-4) + (S)-4-phenyl-2-oxazolidinone (99395-88-7,7480-32-2) → 4-(4-phenyl-2-oxo-oxazolidin-3-yl)-N-propyl-benzamide (572923-17-2)

Guidance literature:

With copper(l) iodide; potassium carbonate; rac-diaminocyclohexane; In 1,4-dioxane; Heating;

DOI:10.1021/jo052060z

upstream raw materials:

4-chloro-N-n-propylbenzamide

(S)-4-phenyl-2-oxazolidinone

4-iodo-N-propyl-benzamide

4-bromo-N-(propyl)benzamide

Downstream raw materials:

4-(2,2-dioxo-4-phenyl-1,2,3-oxathiazolidin-3-yl)-N-(propyl)benzamide

4-(2-oxo-4-phenyl-1,2,3-oxathiazolidin-3-yl)-N-(propyl)benzamide

4-(2-hydroxy-1-phenylethylamino)-N-(propyl)benzamide

Refernces

• 1、 Ghosh, Arun,Sieser, Janice E.,Riou, Maxime,Cai, Weiling,Rivera-Ruiz, Luis. "Palladium-catalyzed synthesis of N-aryloxazolidinones from aryl chlorides". . p. 2207 - 2210. Retrieved 2007/10/03.