METHYL 10-CHLORO-10-OXODECANOATE

Base Information

• Chemical Name: METHYL 10-CHLORO-10-OXODECANOATE
• CAS No.: 14065-32-8
• Molecular Formula: C11H19 Cl O3
• Molecular Weight: 234.723
• Hs Code.: 2918300090
• Mol file: 14065-32-8.mol

Synonyms:Nonanoic acid,9-(chloroformyl)-, methyl ester (6CI,8CI); 9-Carbomethoxynonanoyl chloride;9-Methoxycarbonylnonanoyl chloride; Methyl 10-chloro-10-oxodecanoate; Methyl9-(chloroformyl)nonanoate

Chemical Property of METHYL 10-CHLORO-10-OXODECANOATE

Chemical Property:

• Vapor Pressure: 0.00266mmHg at 25°C
• Melting Point: 16.5-17 °C
• Refractive Index: n20/D 1.453(lit.)
• Boiling Point: 286.3°Cat760mmHg
• Flash Point: 102.4°C
• PSA: 43.37000
• Density: 1.056g/cm³
• LogP: 3.04560

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl 10-chloro-10-oxodecanoate 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 34
• Safety Statements: 16-23-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Methyl 10-chloro-10-oxodecanoate may be used in the preparation of the following:methyl 10-[2-methoxy-4-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]-10-oxodecanoatefluorescein-derivatives of Necrostatin-3methyl 10-oxo-10-(Pyren-3-yl)decanoate

Technology Process of METHYL 10-CHLORO-10-OXODECANOATE

There total 7 articles about METHYL 10-CHLORO-10-OXODECANOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

sebacic acid mono methyl ester (818-88-2) → methyl 10-chloro-10-oxodecanoate (14065-32-8)

Guidance literature:

With thionyl chloride; at 50 ℃; for 3h;

DOI:10.1021/jm950872p

Reference yield:

dimethyl sebacate (106-79-6) → methyl 10-chloro-10-oxodecanoate (14065-32-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / KOH / methanol; acetonitrile; diethyl ether / 54 h / 0 °C

2: (COCl)2 / toluene / 4 h / 20 °C

With potassium hydroxide; oxalyl dichloride; In methanol; diethyl ether; toluene; acetonitrile;

DOI:10.1016/j.bmcl.2004.06.003

Reference yield:

1,10-decanedioic acid (111-20-6,26776-29-4) → methyl 10-chloro-10-oxodecanoate (14065-32-8)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂SO₄ / Heating

2: Ba(OH)2 / methanol / 20 h / 20 °C

3: SOCl₂ / benzene / Heating

With barium dihydroxide; thionyl chloride; sulfuric acid; In methanol; benzene;

upstream raw materials:

methanol

sebacoyl chloride

sebacic acid mono methyl ester

dimethyl sebacate

Downstream raw materials:

10-oxo-decanoic acid methyl ester

methyl 10-oxomyristate

10-oxo-10-phenyl-decanoic acid methyl ester

10-Keto-12-methyltetradecansaeuremethylester

Refernces

• 1、 Arnarson,Elworthy. "Effects of structural variations of non-ionic surfactants on micellar properties and solubilization: surfactants containing very long hydrocarbon chains". . p. 141 - 144. Retrieved 1981.
• 2、 Andronova, Valeriya L.,Charushin, Valery N.,Galegov, Georgii А.,Krasnov, Victor P.,Levit, Galina L.,Vozdvizhenskaya, Olga А.. "Synthesis and antiherpetic activity of novel purine conjugates with 7,8-difluoro-3-methyl-3,4-dihydro-2H-1,4-benzoxazine". . p. 490 - 497. Retrieved 2021/06/26.
• 3、 Gao, Min,Lee, Sun Hyeok,Park, Sang Hyuk,Ciaramicoli, Larissa Miasiro,Kwon, Haw-Young,Cho, Heewon,Jeong, Joseph,Chang, Young-Tae. "Neutrophil-Selective Fluorescent Probe Development through Metabolism-Oriented Live-Cell Distinction". supporting information. p. 23743 - 23749. Retrieved 2021/10/14.