4-Chlorothiophene-2-carboxylic acid

Base Information

Chemical Name:4-Chlorothiophene-2-carboxylic acid
CAS No.:59614-95-8
Molecular Formula:C5H3ClO2S
Molecular Weight:162.597
Hs Code.:2934999090
European Community (EC) Number:807-632-3
UNII:59T73WM4VY
Mol file:59614-95-8.mol

Synonyms:4-Chlorothiophene-2-carboxylic acid;59614-95-8;4-chloro-2-thiophenecarboxylic acid;721450-30-2;2-Thiophenecarboxylic acid, 4-chloro-;4-CHLOROTHIOPHENE-2-CARBOXYLICACID;4-chloro-thiophene-2-carboxylic acid;MFCD00082876;2-Carboxy-4-chlorothiophene;SCHEMBL788121;59T73WM4VY;JWQMRBBWZUKWFJ-UHFFFAOYSA-N;BCP27858;4-Chloro-2-thiophene Carboxylic Acid;4-chloranylthiophene-2-carboxylic acid;AKOS006272687;PB25964;PS-4978;SB10366;SY046793;CS-0040858;FT-0733762;EN300-107803;A837434;A851041;J-515212;J-515213

Suppliers and Price of 4-Chlorothiophene-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Chlorothiophene-2-carboxylicAcid
50mg
$ 85.00

SynQuest Laboratories
4-Chlorothiophene-2-carboxylic acid 95%
250 mg
$ 128.00

SynQuest Laboratories
4-Chlorothiophene-2-carboxylic acid 95%
1 g
$ 480.00

Matrix Scientific
4-Chlorothiophene-2-carboxylicacid 95+%
1g
$ 941.00

J&W Pharmlab
4-Chloro-thiophene-2-carboxylicacid 97%
5g
$ 3998.00

Crysdot
4-Chlorothiophene-2-carboxylicacid 97%
1g
$ 297.00

Crysdot
4-Chlorothiophene-2-carboxylicacid 97%
10g
$ 1436.00

Crysdot
4-Chlorothiophene-2-carboxylicacid 97%
5g
$ 891.00

Chemenu
4-chlorothiophene-2-carboxylicacid 97%
5g
$ 842.00

Chemenu
4-chlorothiophene-2-carboxylicacid 97%
10g
$ 1356.00

Total 30 raw suppliers

Chemical Property of 4-Chlorothiophene-2-carboxylic acid

Chemical Property:

Vapor Pressure:0.000585mmHg at 25°C
Melting Point:131-132 °C(Solv: methanol (67-56-1))
Refractive Index:1.623
Boiling Point:298°C at 760 mmHg
PKA:3.50±0.10(Predicted)
Flash Point:134°C
PSA：65.54000
Density:1.572g/cm³
LogP:2.09970
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:161.9542282
Heavy Atom Count:9
Complexity:128

Purity/Quality:

99%, ^*data from raw suppliers

4-Chlorothiophene-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(SC=C1Cl)C(=O)O

Technology Process of 4-Chlorothiophene-2-carboxylic acid

There total 2 articles about 4-Chlorothiophene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 17249-80-8
3-chlorothiophene

: 124-38-9,18923-20-1
carbon dioxide

: 59337-89-2
3-chlorothiophene-2-carboxylic acid

: 59614-95-8
4-Chloro-2-thiophenecarboxylic Acid

Guidance literature:: 3-chlorothiophene; With n-butyllithium; In tetrahydrofuran; at -78 ℃;

carbon dioxide; In tetrahydrofuran; at -78 ℃; for 2h;
DOI:10.1021/acs.jmedchem.6b00085

Reference yield:

: 34730-20-6
1-(4-chlorothiophen-2-yl)ethan-1-one

: 59614-95-8
4-Chloro-2-thiophenecarboxylic Acid

Guidance literature:: With sodium hydroxide; chlorine; Yield given. Multistep reaction; 1) H₂O, -10 deg C, 2) 50 deg C;
DOI:10.1007/BF00809649